Small animal optoacoustic tomography system for molecular imaging of contrast agents

2016 ◽  
Author(s):  
Richard Su ◽  
Anton Liopo ◽  
Sergey A. Ermilov ◽  
Alexander A. Oraevsky
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Small Animal ◽  
Optoacoustic Tomography ◽  
Tomography System

scholarly journals A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging

2009 ◽  
Vol 80 (4) ◽  
pp. 043701 ◽  
Author(s):  
Dax Kepshire ◽  
Niculae Mincu ◽  
Michael Hutchins ◽  
Josiah Gruber ◽  
Hamid Dehghani ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Small Animal ◽  
Microcomputed Tomography ◽  
Fluorescence Tomography ◽  
Tomography System

scholarly journals A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yuyang Li ◽  
Kian Shaker ◽  
Jakob C. Larsson ◽  
Carmen Vogt ◽  
Hans M. Hertz ◽  
...  
Keyword(s):  
Contrast Agents ◽  
High Spatial Resolution ◽  
Tumor Imaging ◽  
Small Animal ◽  
Laboratory System ◽  
Fluorescence Tomography ◽  
X Ray ◽  
Tomography System ◽  
Compton Background ◽  
Biological Optimization

Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source. The K-shell emissions of these NPs are spectrally well separated from the X-ray probe and the Compton background, making them suitable for the lab-scale XRF tomography system. Their potential as XRF contrast agents is demonstrated successfully in a small-animal equivalent phantom, confirming the simulation results. The diversity in the NP composition provides a flexible platform for a better design and biological optimization of XRF tomography nanoprobes.

Fluorescence Molecular Imaging of Small Animal Tumor Models

2004 ◽  
Vol 4 (4) ◽  
pp. 419-430 ◽  
Author(s):  
E. Graves ◽  
R. Weissleder ◽  
V. Ntziachristos
Keyword(s):  
Molecular Imaging ◽  
Small Animal ◽  
Tumor Models ◽  
Animal Tumor ◽  
Fluorescence Molecular Imaging

scholarly journals Recent development of nanoparticles for molecular imaging

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170022 ◽  
Author(s):  
Jonghoon Kim ◽  
Nohyun Lee ◽  
Taeghwan Hyeon
Keyword(s):  
Surface Modification ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Multimodal Imaging ◽  
High Sensitivity ◽  
Accurate Diagnosis ◽  
Biological Processes ◽  
Future Perspectives ◽  
Cellular Functions ◽  
Diagnosis Of Diseases

Molecular imaging enables us to non-invasively visualize cellular functions and biological processes in living subjects, allowing accurate diagnosis of diseases at early stages. For successful molecular imaging, a suitable contrast agent with high sensitivity is required. To date, various nanoparticles have been developed as contrast agents for medical imaging modalities. In comparison with conventional probes, nanoparticles offer several advantages, including controllable physical properties, facile surface modification and long circulation time. In addition, they can be integrated with various combinations for multimodal imaging and therapy. In this opinion piece, we highlight recent advances and future perspectives of nanomaterials for molecular imaging. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

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