Clinical impact of NIR guided surgery (Conference Presentation)

Author(s):  
Fernando Dip
2014 ◽  
Vol 1 (3) ◽  
pp. 81-85 ◽  
Author(s):  
Sung Kwon Kim ◽  
Seung Hong Choi ◽  
Yong Hwy Kim ◽  
Chul-Kee Park

Abstract Background To evaluate the clinical impact of fluorescence-guided surgery (FGS) in glioblastoma, we analyzed the clinical data of 80 consecutive patients operated on by a single surgeon with or without 5-aminolevulinic acid (5-ALA). Methods We compared 3-dimensional volumetric extent of resection and clinical outcomes between 40 consecutive patients undergoing resection using a white-light (WL) microscope and 40 subsequent consecutive patients undergoing resection using FGS with 5ALA. Results By introducing FGS, there was a significant difference in the mean volumetric extent of the resection rate of T1-enhancing lesions (84.7% in the white-light group and 97.0% in the 5-ALA group, P = .002). The complete resection rate was improved from 43% to 80%, and the proportion of resections that were <80% was reduced from 26% to 4% by FGS. The median progression-free survival was significantly better in the 5-ALA group (18.0 months vs. 6.0 months; P = .001). Although the immediate postoperative functional status was slightly worse in the 5-ALA group, this trend had reversed itself by 3 months postoperatively. Conclusions The present study adds practical evidence of the clinical impact of 5-ALA FGS on glioblastomas from the surgeon's standpoint.


2005 ◽  
Vol 173 (4S) ◽  
pp. 225-225
Author(s):  
Peter Olbert ◽  
Andres J. Schrader ◽  
Axel Hegele ◽  
Zoltan Varga ◽  
Axel Heidenreich ◽  
...  

2006 ◽  
Vol 175 (4S) ◽  
pp. 395-395
Author(s):  
Nancy J. Tresser ◽  
Elena V. Zagaynova ◽  
Olga S. Streltsova ◽  
Natalia D. Gladkova ◽  
Vladislav A. Kamensky ◽  
...  

Ob Gyn News ◽  
2008 ◽  
Vol 43 (3) ◽  
pp. 21
Author(s):  
Miriam E. Tucker
Keyword(s):  

2017 ◽  
Vol 22 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Bastianina Contena ◽  
Stefano Taddei

Abstract. Borderline Intellectual Functioning (BIF) refers to a global IQ ranging from 71 to 84, and it represents a condition of clinical attention for its association with other disorders and its influence on the outcomes of treatments and, in general, quality of life and adaptation. Furthermore, its definition has changed over time causing a relevant clinical impact. For this reason, a systematic review of the literature on this topic can promote an understanding of what has been studied, and can differentiate what is currently attributable to BIF from that which cannot be associated with this kind of intellectual functioning. Using Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, we have conducted a review of the literature about BIF. The results suggest that this condition is still associated with mental retardation, and only a few studies have focused specifically on this condition.


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