In this research work, low refractive index (RI) detection done on multi-core photonic crystal fiber (PCF) based highly sensitive surface plasmon resonance (SPR) sensor is propounded. Sensing the changes in neighboring medium’s refractive index is done by placing the plasmonic material i.e. Silver (Ag) over the crystal structure of fiber. On top of the Silver, a threadlike film of titanium dioxide (TiO2) is deposited to prevent oxidation of plasmonic material silver. Peak wavelength sensitivity thus achieved by this sensor is 127,600 nm/RIU and similarly, peak amplitude sensitivity achieved is 2561 RIU-1, respectively. Subsequently making this sensor suitable candidate for various applications such as biosensing, sensing organic compounds and chemicals, inspecting pharmaceuticals and other detections.