The hot deformation behavior of TC27 titanium alloy at the temperatures of 900-1150 °C and the strain rate of 0.01-10 s-1, the height reduction of 70%, was investigated in the isothermal compression test to identify the optimal extrusion parameters. The processing-map of TC27 titanium alloy was constructed based on dynamic materials model (DMM) and principle of Prasad*s instability. The conclusion shows that temperature and strain rate of deformation had a great influence on flow stress. At the beginning of deformation, the flow stress increased quickly with the augment of true strain and decreased slowly after flow stress reaching to the maximum value. Finally, flow stress tended to relatively stable condition. The flow stress decreased with the increase of temperature and increased with the increase of strain rate. The TC27 titanium alloy was sensitive to temperature and strain rate. Processing-map exhibited two peak efficiencies of power dissipation; one peak was 49% at 900°C/0.01 s-1, which dynamic recovery occured. The other peak was also 49% at 1050 °C /0.01s-1, which dynamic recrystallization occured in the domain. Besides, there were two instability areas in the processing-map which should be avoided during the extrusion. Therefore, in order to obtain the satisfactory properties, the parameters that 1050 °C and 0.01 s-1 were selected in the extrusion.