Objective: The aim of this study was to validate the accuracy of a new automatic method for scar segmentation and compare its performance with that of two other frequently used segmentation algorithms.Methods: Twenty-six late gadolinium enhancement cardiovascular magnetic
resonance images of diseased hearts were segmented by the full width at half maximum (FWHM) method, the n standard deviations (nSD) method, and our new automatic method. The results of the three methods were compared with the consensus ground truth obtained by manual segmentation
of the ventricular boundaries.Results: Our automatic method yielded the highest Dice score and the lowest volume difference compared with the consensus ground truth segmentation. The nSD method produced large variations in the Dice score and the volume difference. The FWHM
method yielded the lowest Dice score and the greatest volume difference compared with the automatic, 6SD, and 8SD methods, but resulted in less variation when different observers segmented the images.Conclusion: The automatic method introduced in this study is highly reproducible
and objective. Because it requires no manual intervention, it may be useful for processing large datasets produced in clinical applications.