Hyperpolarized129Xe magnetic resonance imaging of a rat model of transient Ischemic Stroke

2009 ◽  
Author(s):  
Ronn P. Walvick ◽  
Birgul Bastan ◽  
Austin Reno ◽  
Joey Mansour ◽  
Yanping Sun ◽  
...  
2020 ◽  
pp. 096452842092029
Author(s):  
Zuanfang Li ◽  
Minguang Yang ◽  
Yunjiao Lin ◽  
Shengxiang Liang ◽  
Weilin Liu ◽  
...  

Background To evaluate whether electroacupuncture (EA) treatment at LI11 and ST36 could reduce motor impairments and enhance brain functional recovery in a rat model of ischemic stroke. Methods A rat model of middle cerebral artery occlusion (MCAO) was established. EA at LI11 and ST36 was started at 24 h (MCAO + EA group) after ischemic stroke modeling. Untreated model (MCAO) and sham-operated (Sham) groups were included as controls. The neurological deficits of all groups were assessed using modified neurologic severity scores (mNSS) at 24 h and 14 days after MCAO. To further investigate the effect of EA on infarct volume and brain function, functional magnetic resonance imaging was used to estimate the size of the brain lesions and neural activities of each group at 14 days after ischemic stroke. Results EA treatment of MCAO rats led to a significant reduction in the infarct volumes accompanied by functional recovery, reflected in improved mNSS outcomes and motor functional performances. Furthermore, functional connectivity between the left motor cortex and left cerebellum posterior lobe, right motor cortex, left striatum and bilateral sensory cortex were decreased in MCAO group but increased after EA treatment. Conclusion EA at LI11 and ST36 could enhance the functional connectivity between the left motor cortex and the motor function-related brain regions, including the motor cortex, sensory cortex and striatum, in rats. EA exhibits potential as a treatment for ischemic stroke.


2002 ◽  
Vol 42 (7) ◽  
pp. 281-288
Author(s):  
Keisuke MARUYAMA ◽  
Tsuneyoshi EGUCHI ◽  
Shigeo SORA ◽  
Masafumi IZUMI ◽  
Hirofumi HIYAMA ◽  
...  

2012 ◽  
Vol 10 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Tanja Sommer ◽  
Martin Meier ◽  
Frank Bruns ◽  
Reinhard Pabst ◽  
Gerhard Breves ◽  
...  

1991 ◽  
Vol 6 (4) ◽  
pp. 355 ◽  
Author(s):  
Jae Kyu Roh ◽  
Kwang Kuk Kim ◽  
Moon Hee Han ◽  
Kee Hyun Chang ◽  
Heung Joon Kim ◽  
...  

Stroke ◽  
2018 ◽  
Vol 49 (10) ◽  
pp. 2337-2344 ◽  
Author(s):  
J. Scott McNally ◽  
Peter J. Hinckley ◽  
Akihiko Sakata ◽  
Laura B. Eisenmenger ◽  
Seong-Eun Kim ◽  
...  

2019 ◽  
Vol 18 (2) ◽  
pp. 35-40
Author(s):  
R. Kh. Aldatov ◽  
V. A. Fokin

The most important benefit that imaging provides to a patient with ischemic stroke is the rapid identification of those patients who are most likely to benefit from emergency treatment. This group includes patients who suffer from severe neurological symptoms due to the occlusion of the main artery, and those who are candidates for recanalization by intravenous thrombolysis or intra-arterial intervention to remove blockage.Objective – to assess the sensitivity and significance of computed tomography and magnetic resonance imaging in early diagnosis of infarction foci.Material and methods. The results of radiologic studies of 89 patients with a clinical picture, suspected of acute ischemic cerebral circulation disorders, received in the first 24 hours from the moment of development of neurological symptoms were analyzed.Results. As a result of our study, it was shown that in the first group of patients received in the first 4.5 h from the moment of development of neurological symptoms of CT-signs of stroke were not detected in 16 (76 %) of 21 patients, while those received in the first 24 h from the moment of development of neurological symptoms of CT-signs of stroke were not detected in 14 (28 %) of 50 patients, determined by the symptom of strengthening of the artery, loss of differentiation between gray and white matter of the brain, smoothness of cortical furrows and the appearance of a zone of reduced densitometric density brain substances (<22HU). The difficulties of diagnosis in some patients on CT were the size and localization of ischemic areas (lacunar, stem strokes). In group II of 18 patients of the study, native MRI revealed signs of ischemic areas in 10 patients out of 10, complex CT and MRI to determined areas of hypoperfusion in 8 patients out of 8.Conclusion. CT is the most widely used imaging technique for cerebral infarction with high sensitivity to intracerebral hemorrhage, high specificity in ischemia, but low sensitivity to the detection of ischemic changes is a limiting factor. The data obtained confirm that MRI is a reliable method of diagnosing ischemic stroke. The most sensitive in the diagnosis of ischemic changes in the acute stage of development by using DWI (b1000).


1988 ◽  
Vol 140 (5 Part 2) ◽  
pp. 1178-1180 ◽  
Author(s):  
Howard M. Landa ◽  
Victoria Gylys-Morin ◽  
Robert F. Mattery ◽  
Paul Hajek ◽  
Henry F. Krous ◽  
...  

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