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Biosystem of the human body is viewed as a whole. First of all adequate mathematical machine selection and class of biosystems needs to be assigned for creation of mathematical model of biological system. Biosystem has two types of appoach. One of them is supposed to be a simple approach, the other is likely to be very complex – indexed approach. Different biosystems with determination properties are usually described by differential and integral equations, linear and nonlinear algebra. In some cases, algebraic polynoms with timed argument are used for presenting determined biosystem dynamics. Adequate mathematical modeling machine, probability theory, Markov and random processes theory and the laws are applied for the description of likely characterized biosystems. Key words: biosystem, biocybernetic issues, differential and integral equations, mathematical model, Markov chains, Bayes method, artifical neural networks