SU-C-207-07: Quantification of Coronary Artery Cross-Sectional Area in CT Angiography Using Integrated Density: A Phantom Study

In eight healthy male volunteers (cardiologists; age 36 ± 5 yr), bicycle spiroergometry, Doppler echocardiography, and quantitative coronary angiography with intracoronary Doppler measurements before and after completion of a physical endurance exercise program of >5 mo duration were performed. Maximum oxygen uptake increased from 46 ± 6 to 54 ± 5 ml · kg−1 · min−1( P = 0.04), maximum ergometric workload changed from 3.8 ± 0.3 to 4.4 ± 0.3 W/kg ( P = 0.001), and left ventricular mass index increased from 82 ± 18 to 108 ± 29 g/m2 ( P = 0.001). The right, left main, and left anterior descending coronary artery cross-sectional area increased significantly in repsonse to exercise. Before versus at the end of the exercise program, flow-induced left anterior descending coronary artery cross-sectional area was 10.1 ± 3.5 and 11.0 ± 3.9 mm2, respectively ( P = 0.03), nitroglycerin-induced left coronary calibers increased significantly, and coronary flow velocity reserve changed from 3.8 ± 0.8 to 4.5 ± 0.7 ( P = 0.001). Left coronary artery correlated significantly with ventricular mass and maximum oxygen uptake, and coronary flow velocity reserve was significantly associated with maximum workload.

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Influence of left ventricular mass on coronary artery cross-sectional area

The American Journal of Cardiology ◽

10.1016/0002-9149(87)90927-1 ◽

1987 ◽

Vol 59 (15) ◽

pp. 1395-1397 ◽

Cited By ~ 50

Author(s):

James H. O'keefe ◽

Robert M. Owen ◽

Alfred A. Bove

Keyword(s):

Coronary Artery ◽

Left Ventricular Mass ◽

Left Ventricular ◽

Cross Sectional Area ◽

Sectional Area ◽

Cross Sectional ◽

Ventricular Mass

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Influence of malformation of right coronary artery originating from the left sinus on the hemodynamic environment

10.21203/rs.2.22271/v1 ◽

2020 ◽

Author(s):

Mengyang Cong ◽

Xingming Xu ◽

Jianfeng Qiu ◽

Shun Dai ◽

Chuanzhi Chen ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Arteries ◽

Right Coronary Artery ◽

Clinical Symptoms ◽

Element Model ◽

Cross Sectional Area ◽

Sectional Area ◽

Cross Sectional ◽

The Cross ◽

The Right

Abstract Background: The Anomalous origin of the Right Coronary Artery (RCA) from the Left Coronary artery sinus(AORL) is one of the abnormal origins of the coronary arteries. Most of these issues seldom have effects on human health, but some individuals may have symptoms such as myocardial ischaemia or even sudden death. Recently, researchers are studying AORL through clinical cases, but study based on computational fluid dynamics (CFD) is rarely seen. In this study, haemodynamic changes between normal origin of the RCA and AORL are compared according to numerical simulation results.Methods: Realistic three-dimensional models of 16 normal right coronary arteries and 26 abnormal origins of the right coronary arteries were reconstructed, respectively. The blood flow was numerically simulated using software ANSYS. This study involves one-way fluid-solid coupling finite element model in which the blood is assumed to be incompressible Newtonian fluid, and the vessel is assumed to be isotropic, linear elastic material.Results: The differences of the cross-sectional area at the inlet between the normal group and the abnormal group was significant ( P <0.0001). There were significant differences in the volumetric flow ( P <0.0001) and the pressure ( P =0.0001). There were positive correlations with the ratio of the cross-sectional area of the RCA to the inlet area of the ascending aorta (AAO) and the ratio of the inlet volumetric flow of the RCA to the volumetric flow of the AAO, in both the normal ( P =0.0001, r=0.8198) and abnormal ( P =0.0199, r=0.4925) group.Conclusion: This study shows that the cross-sectional area of the inlet of AORL may cause ischaemia symptoms, and the results may contribute to the further understanding of the clinical symptoms of AORL based on the haemodynamics.

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