Influence of left ventricular mass on coronary artery cross-sectional area

Background and Objectives: Resistance to ASA (ASAres) is a multifactorial phenomenon defined as insufficient reduction of platelet reactivity through incomplete inhibition of thromboxane A2 synthesis. The aim is to reassess the prevalence and predictors of ASAres in a contemporary cohort of coronary artery disease (CAD) patients (pts) on stable therapy with ASA, 75 mg o.d. Materials and Methods: We studied 205 patients with stable CAD treated with daily dose of 75 mg ASA for a minimum of one month. ASAres was defined as ARU (aspirin reaction units) ≥550 using the point-of-care VerifyNow Aspirin test. Results: ASAres was detected in 11.7% of patients. Modest but significant correlations were detected between ARU and concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) (r = 0.144; p = 0.04), body weight, body mass index, red blood cell distribution width, left ventricular mass, and septal end-systolic thickness, with trends for left ventricular mass index and prothrombin time. In multivariate regression analysis, log(NT-proBNP) was identified as the only independent predictor of ARU—partial r = 0.15, p = 0.03. Median concentrations of NT-proBNP were significantly higher in ASAres patients (median value 311.4 vs. 646.3 pg/mL; p = 0.046) and right ventricular diameter was larger, whereas mean corpuscular hemoglobin concentration was lower as compared to patients with adequate response to ASA. Conclusions: ASAres has significant prevalence in this contemporary CAD cohort and NT-proBNP has been identified as the independent correlate of on-treatment ARU, representing a predictor for ASAres, along with right ventricular enlargement and lower hemoglobin concentration in erythrocytes.

Download Full-text

D010 Effects of nicotine gum on cross-sectional area of coronary artery stenoses

American Journal of Hypertension ◽

10.1016/s0895-7061(97)90969-9 ◽

1998 ◽

Vol 11 (4) ◽

pp. 71A

Author(s):

A NITENBERG

Keyword(s):

Coronary Artery ◽

Cross Sectional Area ◽

Sectional Area ◽

Nicotine Gum ◽

Cross Sectional ◽

Coronary Artery Stenoses

Download Full-text

Serum BNP Concentration and Left Ventricular Mass in CAPD and Automated Peritoneal Dialysis Patients

Peritoneal Dialysis International ◽

10.1177/089686080702700612 ◽

2007 ◽

Vol 27 (6) ◽

pp. 663-668 ◽

Cited By ~ 14

Author(s):

Nüket Bavbek ◽

Hatice Akay ◽

Mustafa Altay ◽

Ebru Uz ◽

Faruk Turgut ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Left Ventricular Mass ◽

Clinical Evidence ◽

Left Ventricular Mass Index ◽

Left Ventricular ◽

Cross Sectional ◽

Ventricular Mass ◽

Ultra Filtration ◽

Healthy Control ◽

Echocardiographic Findings

Objective To compare ultrafiltration under continuous ambulatory peritoneal dialysis (CAPD) and automated PD (APD), disclosing potential effects on serum B-type natriuretic peptide (BNP) levels and echocardiographic findings. Patients and Methods This cross-sectional clinical study included 32 patients on CAPD and 30 patients on APD without clinical evidence of heart failure or hemodynamically significant valvular heart disease. Peritoneal equilibration tests, BNP levels, and echocardiographic measurements were performed in each subject. BNP measurements were also performed in 24 healthy control subjects. Results Patients on APD had lower ultrafiltration and higher values of BNP and left ventricular mass index (LVMI) compared with patients on CAPD (respectively: 775 ± 160 vs 850 ± 265 mL, p = 0.01; 253.23 ± 81.64 vs 109.42 ± 25.63 pg/mL, p = 0.001; 185.12 ± 63.50 vs 129.30 ± 40.95 g/m2, p = 0.001). This occurred despite higher mean dialysate glucose concentrations and far more extensive use of icodextrin in the APD group. Conclusion Treatment with APD is associated with higher plasma BNP levels and LVMI compared to CAPD. This may be the result of chronic fluid retention caused by lower ultra-filtration in APD patients.

Download Full-text

Left Ventricular Mass is Independently Related to Coronary Artery Atherosclerotic Burden

Journal of Thoracic Imaging ◽

10.1097/rti.0000000000000511 ◽

2020 ◽

Vol Publish Ahead of Print ◽

Cited By ~ 1

Author(s):

Jeroen Walpot ◽

Samia Massalha ◽

Alomgir Hossain ◽

Gary R. Small ◽

Andrew M. Crean ◽

...

Keyword(s):

Coronary Artery ◽

Left Ventricular Mass ◽

Left Ventricular ◽

Atherosclerotic Burden ◽

Ventricular Mass

Download Full-text

Left ventricular wave speed

Journal of Applied Physiology ◽

10.1152/jappl.2001.91.6.2531 ◽

2001 ◽

Vol 91 (6) ◽

pp. 2531-2536 ◽

Cited By ~ 12

Author(s):

Jiun-Jr Wang ◽

Kim H. Parker ◽

John V. Tyberg

Keyword(s):

Wave Speed ◽

Pulse Generator ◽

Diastolic Pressure ◽

Left Ventricular ◽

Cross Sectional Area ◽

Sectional Area ◽

Cross Sectional ◽

Pressure Transducers ◽

Pressure Area ◽

Axis Length

Left ventricular (LV) wave speed (LVWS) was studied experimentally and confirmed in theory. Combining the definition of elastance (E) with the equations for the conservation of mass and momentum shows that LVWS is proportional to the square root of E LA, where L is long-axis length and A is the cross-sectional area, and the density of the blood. (We defined E LA = γ, where γ is compressibility.) We studied nine open chest, anesthetized dogs, three of which were studied during caval constriction when LV end-diastolic pressure was ≤0 mmHg. The hearts were paced at ∼90 beats/min, and LV cross-sectional area was measured by using two pairs of ultrasonic crystals; E was calculated from the LV pressure-area loop. A pulse generator was connected to the LV apex, and LVWS was measured by using two pressure transducers: one near the apex and the other near the base. Their distance was measured roentgenographically and compared with the diameter of a reference ball. LVWS ranged from ∼1 m/s during diastole to ∼10 m/s during systole. The slope of the log c(where c is wave speed) vs. log γ was 0.546, which is in agreement with theory (0.5). When γ ≤ 0, LVWS was ∼1.5 m/s.

Download Full-text