MO-FG-CAMPUS-TeP3-02: Benchmarks of a Proton Relative Biological Effectiveness (RBE) Model for DNA Double Strand Break (DSB) Induction in the FLUKA, MCNP, TOPAS, and RayStation™ Treatment Planning System

2016 ◽  
Vol 43 (6Part32) ◽  
pp. 3727-3728
Author(s):  
R Stewart ◽  
S Streitmatter ◽  
E Traneus ◽  
V Moskvin ◽  
J Schuemann
Keyword(s):  
Treatment Planning ◽  
Relative Biological Effectiveness ◽  
Strand Break ◽  
Double Strand Break ◽  
Planning System ◽  
Treatment Planning System ◽  
Dna Double Strand Break ◽  
Biological Effectiveness

Rapid MCNP simulation of DNA double strand break (DSB) relative biological effectiveness (RBE) for photons, neutrons, and light ions

2015 ◽  
Vol 60 (21) ◽  
pp. 8249-8274 ◽  
Author(s):  
Robert D Stewart ◽  
Seth W Streitmatter ◽  
David C Argento ◽  
Charles Kirkby ◽  
John T Goorley ◽  
...  
Keyword(s):  
Relative Biological Effectiveness ◽  
Strand Break ◽  
Double Strand Break ◽  
Mcnp Simulation ◽  
Dna Double Strand Break ◽  
Light Ions ◽  
Biological Effectiveness

scholarly journals Comparative photon and proton dosimetry for patients with mediastinal lymphoma in the era of Monte Carlo treatment planning and variable relative biological effectiveness

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yolanda D. Tseng ◽  
Shadonna M. Maes ◽  
Gregory Kicska ◽  
Patricia Sponsellor ◽  
Erik Traneus ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Proton Therapy ◽  
Breast Tissue ◽  
Relative Biological Effectiveness ◽  
Planning System ◽  
Treatment Planning System ◽  
Target Coverage ◽  
Mediastinal Lymphoma ◽  
Biological Effectiveness

Abstract Background Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative biological effectiveness (vRBE). Using a commercially available Monte Carlo (MC) treatment planning system, we compared various dosimetric endpoints between proton PBA, proton MC, and photon treatment plans among patients with mediastinal lymphoma. Methods Eight mediastinal lymphoma patients with both free breathing (FB) and deep inspiration breath hold (DIBH) CT simulation scans were analyzed. The original PBA plans were re-calculated with MC. New proton plans that used MC for both optimization and dose calculation with equivalent CTV/ITV coverage were also created. A vRBE model, which uses a published model for DNA double strand break (DSB) induction, was applied on MC plans to study the potential impact of vRBE on cardiac doses. Comparative photon plans were generated on the DIBH scan. Results Re-calculation of FB PBA plans with MC demonstrated significant under coverage of the ITV V99 and V95. Target coverage was recovered by re-optimizing the PT plan with MC with minimal change to OAR doses. Compared to photons with DIBH, MC-optimized FB and DIBH proton plans had significantly lower dose to the mean lung, lung V5, breast tissue, and spinal cord for similar target coverage. Even with application of vRBE in the proton plans, the putative increase in RBE at the end of range did not decrease the dosimetric advantages of proton therapy in cardiac substructures. Conclusions MC should be used for PT treatment planning of mediastinal lymphoma to ensure adequate coverage of target volumes. Our preliminary data suggests that MC-optimized PT plans have better sparing of the lung and breast tissue compared to photons. Also, the potential for end of range RBE effects are unlikely to be large enough to offset the dosimetric advantages of proton therapy in cardiac substructures for mediastinal targets, although these dosimetric findings require validation with late toxicity data.

Monte Carlo simulations of therapeutic proton beams for relative biological effectiveness of double-strand break

2011 ◽  
Vol 88 (1-2) ◽  
pp. 158-163 ◽  
Author(s):  
Chun-Ching Wang ◽  
Y. Hsiao ◽  
Chung-Chi Lee ◽  
Tsi-Chian Chao ◽  
Chun-Chieh Wang ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Relative Biological Effectiveness ◽  
Strand Break ◽  
Double Strand Break ◽  
Proton Beams ◽  
Biological Effectiveness

Relative Biological Effectiveness of the α-Particle Emitter211At for Double-Strand Break Induction in Human Fibroblasts

2007 ◽  
Vol 167 (3) ◽  
pp. 312-318 ◽  
Author(s):  
Anna Kristina Claesson ◽  
Bo Stenerlöw ◽  
Lars Jacobsson ◽  
Kecke Elmroth
Keyword(s):  
Relative Biological Effectiveness ◽  
Human Fibroblasts ◽  
Strand Break ◽  
Double Strand Break ◽  
Biological Effectiveness
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