SU-F-BRD-16: Relative Biological Effectiveness of Double-Strand Break Induction for Modeling Cell Survival in Pristine Proton Beams of Different Dose-Averaged Linear Energy Transfers

2015 ◽  
Vol 42 (6Part25) ◽  
pp. 3529-3529 ◽  
Author(s):  
C Peeler ◽  
R Taleei ◽  
F Guan ◽  
L Bronk ◽  
D Patel ◽  
...  
Keyword(s):  
Cell Survival ◽  
Relative Biological Effectiveness ◽  
Strand Break ◽  
Double Strand Break ◽  
Proton Beams ◽  
Energy Transfers ◽  
Biological Effectiveness

Monte Carlo simulations of therapeutic proton beams for relative biological effectiveness of double-strand break

2011 ◽  
Vol 88 (1-2) ◽  
pp. 158-163 ◽  
Author(s):  
Chun-Ching Wang ◽  
Y. Hsiao ◽  
Chung-Chi Lee ◽  
Tsi-Chian Chao ◽  
Chun-Chieh Wang ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Relative Biological Effectiveness ◽  
Strand Break ◽  
Double Strand Break ◽  
Proton Beams ◽  
Biological Effectiveness

scholarly journals Impact of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for a 62-MeV Therapeutic Proton Beam

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2997
Author(s):  
Chun-Chieh Chan ◽  
Fang-Hsin Chen ◽  
Ya-Yun Hsiao
Keyword(s):  
Monte Carlo ◽  
Cell Survival ◽  
Relative Biological Effectiveness ◽  
Excision Repair ◽  
Enhancement Ratio ◽  
Proton Beams ◽  
Oxygen Enhancement Ratio ◽  
Biological Effectiveness ◽  
Rmf Model ◽  
Oxygen Enhancement

This study uses the yields of double-strand breaks (DSBs) to determine the relative biological effectiveness (RBE) of proton beams, using cell survival as a biological endpoint. DSB induction is determined when cells locate at different depths (6 positions) along the track of 62 MeV proton beams. The DNA damage yields are estimated using Monte Carlo Damage Simulation (MCDS) software. The repair outcomes are estimated using Monte Carlo excision repair (MCER) simulations. The RBE for cell survival at different oxygen concentrations is calculated using the repair-misrepair-fixation (RMF) model. Using 60Co γ-rays (linear energy transfer (LET) = 2.4 keV/μm) as the reference radiation, the RBE for DSB induction and enzymatic DSB under aerobic condition (21% O2) are in the range 1.0–1.5 and 1.0–1.6 along the track depth, respectively. In accord with RBE obtained from experimental data, RMF model-derived RBE values for cell survival are in the range of 1.0–3.0. The oxygen enhancement ratio (OER) for cell survival (10%) decreases from 3.0 to 2.5 as LET increases from 1.1 to 22.6 keV/μm. The RBE values for severe hypoxia (0.1% O2) are in the range of 1.1–4.4 as LET increases, indicating greater contributions of direct effects for protons. Compared with photon therapy, the overall effect of 62 MeV proton beams results in greater cell death and is further intensified under hypoxic conditions.

Rapid MCNP simulation of DNA double strand break (DSB) relative biological effectiveness (RBE) for photons, neutrons, and light ions

2015 ◽  
Vol 60 (21) ◽  
pp. 8249-8274 ◽  
Author(s):  
Robert D Stewart ◽  
Seth W Streitmatter ◽  
David C Argento ◽  
Charles Kirkby ◽  
John T Goorley ◽  
...  
Keyword(s):  
Relative Biological Effectiveness ◽  
Strand Break ◽  
Double Strand Break ◽  
Mcnp Simulation ◽  
Dna Double Strand Break ◽  
Light Ions ◽  
Biological Effectiveness

scholarly journals A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ramin Abolfath ◽  
Christopher R. Peeler ◽  
Mark Newpower ◽  
Lawrence Bronk ◽  
David Grosshans ◽  
...  
Keyword(s):  
Cell Survival ◽  
Survival Data ◽  
Relative Biological Effectiveness ◽  
Proton Beams ◽  
Biological Effectiveness ◽  
Global Fit

Relative Biological Effectiveness of the α-Particle Emitter211At for Double-Strand Break Induction in Human Fibroblasts

2007 ◽  
Vol 167 (3) ◽  
pp. 312-318 ◽  
Author(s):  
Anna Kristina Claesson ◽  
Bo Stenerlöw ◽  
Lars Jacobsson ◽  
Kecke Elmroth
Keyword(s):  
Relative Biological Effectiveness ◽  
Human Fibroblasts ◽  
Strand Break ◽  
Double Strand Break ◽  
Biological Effectiveness

Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries

2012 ◽  
Vol 57 (20) ◽  
pp. 6671-6680 ◽  
Author(s):  
Karl T Butterworth ◽  
Conor K McGarry ◽  
Ben Clasie ◽  
Alejandro Carabe-Fernandez ◽  
Jan Schuemann ◽  
...  
Keyword(s):  
Cell Survival ◽  
Proton Beam ◽  
Relative Biological Effectiveness ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Biological Effectiveness ◽  
Passive Scattering
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