AbstractBackgroundAdequate neuromuscular control of the knee for active joint stability could be one element to prevent secondary injuries after an anterior cruciate ligament (ACL) injury, either treated conservatively or surgically. However, it is unclear which measurements should be used to assess neuromuscular control of the knee for a safe return to sports (RTS).PurposeTo summarize assessments for neuromuscular control of the knee in athletes after an ACL injury to decide upon readiness towards a successful return to sports (RTS).Study designSystematic review, level of evidence 4MethodsThis systematic review followed the guidelines of Preferred Reporting of Items for Systematic Reviews and Meta-analyses (PRISMA) and has been listed in PROSPERO (CRD42019122188). The databases MEDLINE/PubMed, EMBASE, CINAHL, Cochrane Library, Physiotherapy Evidence Database (PEDro), SPORTDiscus and the Web of Science were searched from inception until March 2019. The search was updated with e-mail alerts from the searched databases until December 2019 and yielded to studies identifying assessments using electromyography (EMG) for neuromuscular control during dynamic activities in patients with an ACL rupture or repair. All included articles were assessed for risk of bias with a modified Downs and Black checklist.ResultsA total of 1178 records were identified through database search. After screening for title, abstract and content regarding in- and exclusion criteria, 31 articles could be included for analysis. Another six articles could be included from hand search of reference lists of the included articles, resulting in a total of 37 articles. Surface EMG was used in all studies as method to assess neuromuscular control. However, there was a wide range of tasks, interventions, muscles measured, and outcomes used. Risk of bias was medium to high due to an unclear description of participants and prior interventions, confounding factors and incompletely reported results.ConclusionsDespite a wide range of EMG outcome measures for neuromuscular control, none was used to decide upon a safe RTS in adult patients after an ACL injury.Clinical relevanceFuture studies should aim at finding valid and reliable assessments for neuromuscular control to judge upon readiness towards RTS.What is known about the subjectThe recurrence rates even after successful surgery and subsequent rehabilitation in ACL patients are high (up to 30%), with a re-injury of the ipsilateral knee, an injury of the opposite leg, muscle injuries on the ipsilateral side or even bilateral consequences and an increased risk for knee osteoarthritis. Furthermore, the diagnostic outcomes used to determine RTS after an ACL tear are numerous. However, they are not always functional and do not sufficiently reflect neuromuscular control abilities of ACL patients. Currently, decisions regarding joint stability for RTS are based on subjective clinical assessments (passive joint stability) and physical test batteries (e.g. hop tests as surrogates for active joint stability). Additional knowledge regarding objective neuromuscular measures closes the gap between the two mentioned currently available evaluations. Up to date, it is unclear which measurements should be used to assess neuromuscular control of the knee for a safe RTS.What this study adds to existing knowledgeSurface electromyography is the choice of method to assess neuromuscular control of the knee during active tasks in adult ACL patients. However, it remains unclear which outcome variables would be best to judge upon readiness towards RTS or which dynamic tasks should be used for RTS.