P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile

2006 ◽  
Vol 34 (9) ◽  
pp. 1468-1479 ◽  
Author(s):  
Shanjun Liu ◽  
Debbie Tam ◽  
Xianghai Chen ◽  
K. Sandy Pang
Keyword(s):  
Small Intestine ◽  
Water Layer ◽  
Rat Small Intestine ◽  
Unstirred Water Layer ◽  
P Glycoprotein ◽  
Digoxin Absorption

Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system

2000 ◽  
Vol 11 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Akira Nakayama ◽  
Hiroshi Saitoh ◽  
Masako Oda ◽  
Masahiko Takada ◽  
Bruce J Aungst
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Efflux System ◽  
P Glycoprotein

scholarly journals Different Absorption Behaviors among Steriod Hormones Due to Possible Interaction with P-Glycoprotein in the Rat Small Intestine.

1999 ◽  
Vol 22 (5) ◽  
pp. 535-538 ◽  
Author(s):  
Akira NAKAYAMA ◽  
Orie EGUCHI ◽  
Masataka HATAKEYAMA ◽  
Hiroshi SAITOH ◽  
Masahiko TAKADA
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
P Glycoprotein

Mechanisms maintaining a low-pH microclimate in the intestine

1985 ◽  
Vol 248 (6) ◽  
pp. G608-G617 ◽  
Author(s):  
Y. F. Shiau ◽  
P. Fernandez ◽  
M. J. Jackson ◽  
S. McMonagle
Keyword(s):  
Small Intestine ◽  
Water Layer ◽  
Low Ph ◽  
Mucosal Surface ◽  
Hydrogen Ion ◽  
Common Phenomenon ◽  
Unstirred Water Layer ◽  
Ion Secretion ◽  
Ion Movement ◽  
Ph Electrode

The presence of an unequilibrated region adjacent to the mucosal surface of the small intestine has long been suggested. Controversy remains as to the characteristics of this region. This study was designed to further define these characteristics. Our studies demonstrated by two independent methods, pH electrode measurement and dye indicator, that a low-pH compartment does exist at the surface of the intestine. The thickness of this microclimate was estimated to be 700 microns, comparable with that described for the unstirred water layer. Maintenance of the low-pH compartment is due to the presence of a mucus coating rather than hydrogen ion secretion. We postulate that the mucus functions as an ampholyte and restricts hydrogen ion movement in its matrix. The acidic microclimate, unstirred water layer, and the mucus coating might in fact represent a common phenomenon.

Involvement of Intestinal P-Glycoprotein in the Restricted Absorption of Methylprednisolone from Rat Small Intestine

1998 ◽  
Vol 87 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Hiroshi Saitoh ◽  
Masataka Hatakeyama ◽  
Orie Eguchi ◽  
Masako Oda ◽  
Masahiko Takada
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
P Glycoprotein

Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine

2006 ◽  
Vol 28 (1-2) ◽  
pp. 34-42 ◽  
Author(s):  
Hiroshi Saitoh ◽  
Yuko Saikachi ◽  
Mikako Kobayashi ◽  
Michiko Yamaguchi ◽  
Masako Oda ◽  
...  
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
P Glycoprotein

Role of P-Glycoprotein as a Secretory Mechanism in Quinidine Absorption from Rat Small Intestine

1998 ◽  
Vol 87 (3) ◽  
pp. 295-299 ◽  
Author(s):  
Yasuharu Emi ◽  
Daisuke Tsunashima ◽  
Ken-ichi Ogawara ◽  
Kazutaka Higaki ◽  
Toshikiro Kimura
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
P Glycoprotein
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