Risk Assessment for Drug-Drug Interaction Caused by Metabolism-Based Inhibition of CYP3A Using Automated in Vitro Assay Systems and Its Application in the Early Drug Discovery Process

2007 ◽  
Vol 35 (7) ◽  
pp. 1232-1238 ◽  
Author(s):  
Akiko Watanabe ◽  
Koichi Nakamura ◽  
Noriko Okudaira ◽  
Osamu Okazaki ◽  
Ken-ichi Sudo
Keyword(s):  
Risk Assessment ◽  
Drug Interaction ◽  
Drug Discovery ◽  
In Vitro Assay ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
Vitro Assay ◽  
Drug Drug Interaction ◽  
Early Drug

Predicting Phospholipidosis: A Fluorescence Noncell Based in Vitro Assay for the Determination of Drug–Phospholipid Complex Formation in Early Drug Discovery

2011 ◽  
Vol 83 (18) ◽  
pp. 6980-6987 ◽  
Author(s):  
Liping Zhou ◽  
Gina Geraci ◽  
Sloan Hess ◽  
Linhong Yang ◽  
Jianling Wang ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Complex Formation ◽  
In Vitro Assay ◽  
Phospholipid Complex ◽  
Vitro Assay ◽  
Early Drug

In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug–drug interaction with methotrexate

2011 ◽  
Vol 43 (1-2) ◽  
pp. 41-49 ◽  
Author(s):  
Robert Elsby ◽  
Lisa Fox ◽  
David Stresser ◽  
Mark Layton ◽  
Caroline Butters ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Drug Interaction ◽  
Drug Drug Interaction

scholarly journals Biophysical methods in early drug discovery

ADMET & DMPK ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 222-241
Author(s):  
Geoffrey Holdgate ◽  
Kevin Embrey ◽  
Alexander Milbradt ◽  
Gareth Davies
Keyword(s):  
Mass Spectrometry ◽  
Drug Discovery ◽  
Assay Development ◽  
Titration Calorimetry ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
Critical Data ◽  
Primary Screening ◽  
The Impact ◽  
Early Drug

Biophysical methods such as mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, and both differential scanning isothermal titration calorimetry are now well established as key components of the early drug discovery process. These approaches are used successfully for a range of activities, including assay development, primary screening, hit confirmation and detailed mechanistic characterisation of compound binding. Matching the speed, sensitivity and information content of the various techniques to the generation of critical data and information required at each phase of the drug discovery process has been key. This review describes the framework by which these methods have been applied in the drug discovery process and provides case studies to exemplify the impact.

Sign in / Sign up

Export Citation Format

Share Document