Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.708 ◽

2002 ◽

Vol 16 (12) ◽

pp. 1225-1231 ◽

Author(s):

Philip R. Tiller ◽

Leslie A. Romanyshyn

Keyword(s):

Liquid Chromatography ◽

Drug Discovery ◽

Mass Spectrometric ◽

Tandem Mass ◽

Discovery Process ◽

Drug Discovery Process ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric ◽

Metabolite Screening ◽

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Integrating qualitative and quantitative liquid chromatography/tandem mass spectrometric analysis to support drug discovery

Rapid Communications in Mass Spectrometry ◽

10.1002/(sici)1097-0231(19991015)13:19<1943::aid-rcm736>3.0.co;2-p ◽

1999 ◽

Vol 13 (19) ◽

pp. 1943-1950 ◽

Author(s):

G. K. Poon ◽

G. Kwei ◽

R. Wang ◽

K. Lyons ◽

Q. Chen ◽

...

Keyword(s):

Liquid Chromatography ◽

Drug Discovery ◽

Mass Spectrometric ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Tandem Mass ◽

Qualitative And Quantitative ◽

Tandem Mass Spectrometric Analysis ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.876 ◽

2002 ◽

Vol 17 (1) ◽

pp. 97-103 ◽

Author(s):

Hong Mei ◽

Yunsheng Hsieh ◽

Cymbylene Nardo ◽

Xiaoying Xu ◽

Shiyong Wang ◽

...

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Drug Discovery ◽

High Performance ◽

Matrix Effects ◽

Mass Spectrometric ◽

Tandem Mass ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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‘LC-electrolyte effects’ improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting pharmacokinetic study for drug discovery

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3129 ◽

2007 ◽

Vol 21 (16) ◽

pp. 2573-2584 ◽

Author(s):

Li Wang ◽

Yan Sun ◽

Feifei Du ◽

Wei Niu ◽

Tong Lu ◽

...

Keyword(s):

Liquid Chromatography ◽

Drug Discovery ◽

Pharmacokinetic Study ◽

Mass Spectrometric ◽

Tandem Mass ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric ◽

Electrolyte Effects

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An improved ultra‐high‐performance liquid chromatography–tandem mass spectrometric method for the quantitation of dexmedetomidine in small volume of pediatric plasma

Biomedical Chromatography ◽

10.1002/bmc.4487 ◽

2019 ◽

Vol 33 (6) ◽

pp. e4487

Author(s):

Ganesh S. Moorthy ◽

Christina Vedar ◽

Ahila S. Moorthy ◽

Janice L. Prodell ◽

Athena F. Zuppa

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Performance ◽

Small Volume ◽

Mass Spectrometric ◽

Spectrometric Method ◽

Tandem Mass ◽

Mass Spectrometric Method ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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A rapid and sensitive liquid chromatography–tandem mass spectrometric method for the determination of hederasaponin B in rat plasma: Application to a pharmacokinetic study

Asian Journal of Pharmaceutical Sciences ◽

10.1016/j.ajps.2016.09.001 ◽

2017 ◽

Vol 12 (4) ◽

pp. 363-369 ◽

Author(s):

Jiaxin Liu ◽

Xueyan Yang ◽

Lin Li ◽

Qili Zhang ◽

Zhaoyan Zhang ◽

...

Keyword(s):

Liquid Chromatography ◽

Pharmacokinetic Study ◽

Mass Spectrometric ◽

Spectrometric Method ◽

Tandem Mass ◽

Mass Spectrometric Method ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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Liquid chromatography–tandem mass spectrometric method for the analysis of fluconazole and evaluation of the impact of phenolic compounds on the concentration of fluconazole in Candida albicans

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2003.11.013 ◽

2004 ◽

Vol 34 (5) ◽

pp. 1117-1124 ◽

Author(s):

Shujuan Sun ◽

Hongxiang Lou ◽

Yanhui Gao ◽

Peihong Fan ◽

Bin Ma ◽

...

Keyword(s):

Candida Albicans ◽

Liquid Chromatography ◽

Phenolic Compounds ◽

Mass Spectrometric ◽

Spectrometric Method ◽

Tandem Mass ◽

Mass Spectrometric Method ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric ◽

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Quantitative liquid chromatography–tandem mass spectrometric analysis of 11-dehydroTXB2 in urine

Prostaglandins & Other Lipid Mediators ◽

10.1016/j.prostaglandins.2004.01.003 ◽

2004 ◽

Vol 73 (1-2) ◽

pp. 103-110 ◽

Author(s):

Naoto Suzuki ◽

Takanori Hishinuma ◽

Satoko Chiba ◽

Toshihide Saga ◽

Hiroki Tsukamoto ◽

...

Keyword(s):

Liquid Chromatography ◽

Mass Spectrometric ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Tandem Mass ◽

Tandem Mass Spectrometric Analysis ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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Development and Validation of Liquid Chromatography-Tandem Mass Spectrometric Method for the Quantification of Ciprofibrate From Human Plasma

Journal of Chromatographic Science ◽

10.1093/chromsci/bmu043 ◽

2014 ◽

Vol 53 (2) ◽

pp. 219-225

Author(s):

D. Shah ◽

D. Mavani ◽

H. Patel ◽

S. Baldania ◽

K. Bhatt ◽

...

Keyword(s):

Liquid Chromatography ◽

Human Plasma ◽

Mass Spectrometric ◽

Spectrometric Method ◽

Tandem Mass ◽

Mass Spectrometric Method ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric ◽

Development And Validation

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A rapid analytical method for cholecalciferol (vitamin D3) in fortified infant formula, milk and milk powder using Diels–Alder derivatisation and liquid chromatography–tandem mass spectrometric detection

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-012-5939-1 ◽

2012 ◽

Vol 403 (5) ◽

pp. 1433-1440 ◽

Author(s):

Grant A. Abernethy

Keyword(s):

Liquid Chromatography ◽

Analytical Method ◽

Milk Powder ◽

Diels Alder ◽

Mass Spectrometric ◽

Tandem Mass ◽

Formula Milk ◽

Infant Formula Milk ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma

Journal of Chromatography B ◽

10.1016/j.jchromb.2012.08.021 ◽

2012 ◽

Vol 905 ◽

pp. 150-154 ◽

Author(s):

Rolf W. Sparidans ◽

Seng Chuan Tang ◽

Luan N. Nguyen ◽

Alfred H. Schinkel ◽

Jan H.M. Schellens ◽

...

Keyword(s):

Liquid Chromatography ◽

Mass Spectrometric ◽

Tandem Mass ◽

Mouse Plasma ◽

Alk Inhibitor ◽

Liquid Chromatography Tandem Mass ◽

Tandem Mass Spectrometric

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