scholarly journals Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene

2013 ◽  
Vol 42 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Jinping Hu ◽  
Li Sheng ◽  
Lei Li ◽  
Xin Zhou ◽  
Fang Xie ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Essential Role ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme

The role of cytochrome P450 enzyme genetic variants in cannabis hyperemesis syndrome—A case report

2021 ◽  
Author(s):  
Maxim Kuzin ◽  
Franziskos Xepapadakos ◽  
Isabel Scharrer ◽  
Marc Augsburger ◽  
Chin‐Bin Eap ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Case Report ◽  
Genetic Variants ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Cannabis Hyperemesis Syndrome

Role of Cytochrome P450 Enzyme Induction in the Metabolic Activation of Benzo[c]phenanthrene in Human Cell Lines and Mouse Epidermis

1997 ◽  
Vol 10 (5) ◽  
pp. 609-617 ◽  
Author(s):  
Heidi J. Einolf ◽  
William T. Story ◽  
Craig B. Marcus ◽  
Michele C. Larsen ◽  
Colin R. Jefcoate ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cell Lines ◽  
Enzyme Induction ◽  
Human Cell ◽  
Metabolic Activation ◽  
Cytochrome P450 Enzyme ◽  
Human Cell Lines ◽  
Mouse Epidermis ◽  
P450 Enzyme

scholarly journals The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox

2018 ◽  
Vol 39 (7) ◽  
pp. 851-859 ◽  
Author(s):  
Lindsay Reed ◽  
Volker M Arlt ◽  
David H Phillips
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzyme ◽  
Cytochrome P450 Enzymes ◽  
Predominant Role ◽  
Enzyme Systems ◽  
P450 Enzyme

Cytochrome P450 enzyme systems have been widely used in vitro to determine the pathways of activation of procarcinogens, but paradoxically, these same enzymes can play a more predominant role in carcinogen detoxification in vivo.

Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants

2003 ◽  
Vol 77 (10) ◽  
pp. 555-560 ◽  
Author(s):  
Miroslav Machala ◽  
Pavel Soucek ◽  
Jir� Neca ◽  
Robert Ulrich ◽  
Jir� Lamka ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Species Comparisons ◽  
Hepatic Cytochrome

Insight into the practical models for prediciting the essential role of the cytochrome P450-mediated biotransformation in emodin-associated hepatotoxicity

Toxicology ◽  
2021 ◽  
Vol 462 ◽  
pp. 152930
Author(s):  
Tingting Zhang ◽  
Xiaomei He ◽  
Lanlan Sun ◽  
Dong Wang ◽  
Shuya Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Essential Role ◽  
Insight Into

scholarly journals Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients

2018 ◽  
Vol 28 (1) ◽  
pp. 56-62
Author(s):  
Cahit Kural ◽  
Arzu Kaya Kocdogan ◽  
Gulcin Güler Şimşek ◽  
Serpil Oğuztüzün ◽  
Pınar Kaygın ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Brain Tissue ◽  
Pituitary Adenomas ◽  
Normal Brain ◽  
Cytochrome P450 Enzyme ◽  
Intracranial Tumors ◽  
Glutathione S Transferase ◽  
Normal Brain Tissue ◽  
Tissue Samples ◽  
P450 Enzyme

Objective: Intracranial tumors are one of the most frightening and difficult-to-treat tumor types. In addition to surgery, protocols such as chemotherapy and radiotherapy also take place in the treatment. Glutathione S-transferase (GST) and cytochrome P450 (CYP) enzymes are prominent drug-metabolizing enzymes in the human body. The aim of this study is to show the expression of GSTP1, GSTM1, CYP1A1, and CYP1B1 in different types of brain tumors and compare our results with those in the literature. Subjects and Methods: The expression of GSTP1, GSTM1, CYP1A1, and CYP1B1 was analyzed using immunostaining in 55 patients with intracranial tumors in 2016–2017. For GST and CYP expression in normal brain tissue, samples of a portion of surrounding normal brain tissue as well as a matched far neighbor of tumor tissue were used. The demographic features of the patients were documented and the expression results compared. Results: The mean age of the patients was 46.72 years; 29 patients were female and 26 were male. Fifty-seven specimens were obtained from 55 patients. Among them, meningioma was diagnosed in 12, metastases in 12, glioblastoma in 9, and pituitary adenoma in 5. The highest GSTP1, GSTM1, and CYP­1A1 expressions were observed in pituitary adenomas. The lowest GSTP1 expression was detected in glioblastomas and the lowest CYP1B1 expression in pituitary adenomas. Conclusion: GSTP1 and CYP expression is increased in intracranial tumors. These results should be confirmed with a larger series and different enzyme subtypes.

Sign in / Sign up

Export Citation Format

Share Document