scholarly journals Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation

2018 ◽  
Vol 46 (5) ◽  
pp. 552-560 ◽  
Author(s):  
Dan-Dan Tian ◽  
Joshua J. Kellogg ◽  
Neşe Okut ◽  
Nicholas H. Oberlies ◽  
Nadja B. Cech ◽  
...  
Keyword(s):  
Green Tea ◽  
Camellia Sinensis ◽  
Test Drug ◽  
Udp Glucuronosyltransferase ◽  
In Vivo Extrapolation

Binding of Inhibitory Fatty Acids Is Responsible for the Enhancement of UDP-Glucuronosyltransferase 2B7 Activity by Albumin: Implications for in Vitro-in Vivo Extrapolation

2007 ◽  
Vol 321 (1) ◽  
pp. 137-147 ◽  
Author(s):  
Andrew Rowland ◽  
Paraskevi Gaganis ◽  
David J. Elliot ◽  
Peter I. Mackenzie ◽  
Kathleen M. Knights ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Udp Glucuronosyltransferase ◽  
In Vivo Extrapolation

Quantitative Prediction of Glucuronidation in Humans Using the In Vitro- In Vivo Extrapolation Approach

2013 ◽  
Vol 13 (11) ◽  
pp. 1343-1352 ◽  
Author(s):  
Baojian Wu ◽  
Dong Dong ◽  
Ming Hu ◽  
Shuxing Zhang
Keyword(s):  
Quantitative Prediction ◽  
In Vivo Extrapolation

Quantitative In Vitro-to-In Vivo Extrapolation: Nominal versus Freely Dissolved Concentration

2021 ◽  
Vol 34 (4) ◽  
pp. 1175-1182
Author(s):  
Luise Henneberger ◽  
Julia Huchthausen ◽  
Niklas Wojtysiak ◽  
Beate I. Escher
Keyword(s):  
Freely Dissolved Concentration ◽  
In Vivo Extrapolation

scholarly journals Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract

2013 ◽  
Vol 49 (2) ◽  
pp. 341-349 ◽  
Author(s):  
Tariq Mahmood ◽  
Naveed Akhtar ◽  
Barkat Ali Khan ◽  
Akhtar Rasul ◽  
Haji M. Shoaib Khan
Keyword(s):  
Green Tea ◽  
Storage Conditions ◽  
Green Tea Extract ◽  
Viscosity Data ◽  
Skin Protection ◽  
Multiple Emulsion ◽  
Multiple Emulsions ◽  
Tea Extract

Complex multiple emulsions have an excellent ability to fill large volumes of functional cosmetic agents. This study was aimed to encapsulate large volume of green tea in classical multiple emulsion and to compare its stability with a multiple emulsion without green tea extract. Multiple emulsions were developed using Cetyl dimethicone copolyol as lipophilic emulsifier and classic polysorbate-80 as hydrophilic emulsifier. Multiple emulsions were evaluated for various physicochemical aspects like conductivity, pH, microscopic analysis, rheology and these characteristics were followed for a period of 30 days in different storage conditions. In vitro and in vivo skin protection tests were also performed for both kinds of multiple emulsions i.e. with active (MeA) and without active (MeB). Both formulations showed comparable characteristics regarding various physicochemical characteristics in different storage conditions. Rheological analysis showed that formulations showed pseudo plastic behavior upon continuous shear stress. Results of in vitro and in vivo skin protection data have revealed that the active formulation has comparable skin protection effects to that of control formulation. It was presumed that stable multiple emulsions could be a promising choice for topical application of green tea but multiple emulsions presented in this study need improvement in the formula, concluded on the basis of pH, conductivity and apparent viscosity data.

In vitro to in vivo extrapolation of biotransformation rates for assessing bioaccumulation of hydrophobic organic chemicals in mammals

2017 ◽  
Vol 36 (7) ◽  
pp. 1934-1946 ◽  
Author(s):  
Yung-Shan Lee ◽  
Justin C. Lo ◽  
S.Victoria Otton ◽  
Margo M. Moore ◽  
Chris J. Kennedy ◽  
...  
Keyword(s):  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
In Vivo Extrapolation
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