In vitro metabolism of slowly cleared GPR139 agonist TAK-041 using rat, dog, monkey and human hepatocyte models (HepatoPac): correlation with in vivo metabolism

Drug Metabolism and Disposition ◽

10.1124/dmd.120.000246 ◽

2020 ◽

pp. DMD-AR-2020-000246

Author(s):

Amin Kamel ◽

Stephen Bowlin ◽

Natalie Hosea ◽

Dimitrios Arkilo ◽

Antonio Laurenza

Keyword(s):

Human Hepatocyte ◽

In Vitro Metabolism ◽

In Vivo Metabolism

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LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[18F]Flubatine—A Positron Emission Tomography Radioligand for Imaging α4β2 Nicotinic Acetylcholine Receptors

Molecules ◽

10.3390/molecules21091200 ◽

2016 ◽

Vol 21 (9) ◽

pp. 1200 ◽

Cited By ~ 7

Author(s):

Friedrich-Alexander Ludwig ◽

René Smits ◽

Steffen Fischer ◽

Cornelius Donat ◽

Alexander Hoepping ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

In Vitro Metabolism ◽

Emission Tomography ◽

In Vivo Metabolism ◽

Nicotinic Acetylcholine ◽

Positron Emission

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3-Fluorophenmetrazine, a fluorinated analogue of phenmetrazine: Studies on in vivo metabolism in rat and human, in vitro metabolism in human CYP isoenzymes and microbial biotransformation in Pseudomonas Putida and wastewater using GC and LC coupled to (HR)-MS techniques

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2016.06.011 ◽

2016 ◽

Vol 128 ◽

pp. 485-495 ◽

Cited By ~ 10

Author(s):

Marie Mardal ◽

Bram Miserez ◽

Richard Bade ◽

Tania Portolés ◽

Markus Bischoff ◽

...

Keyword(s):

Pseudomonas Putida ◽

In Vitro Metabolism ◽

In Vivo Metabolism

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Bridging In Vitro and In Vivo Metabolism and Transport of Faldaprevir in Human Using a Novel Cocultured Human Hepatocyte System, HepatoPac

Drug Metabolism and Disposition ◽

10.1124/dmd.113.055897 ◽

2013 ◽

Vol 42 (3) ◽

pp. 394-406 ◽

Cited By ~ 48

Author(s):

Diane Ramsden ◽

Donald J. Tweedie ◽

Tom S. Chan ◽

Mitchell E. Taub ◽

Yongmei Li

Keyword(s):

Human Hepatocyte ◽

In Vivo Metabolism

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Determination of the stereoselective aspects in in-vitro and in-vivo metabolism of the analgesic meptazinol by high-performance liquid chromatography

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/0378-4347(94)00466-i ◽

1995 ◽

Vol 663 (2) ◽

pp. 315-326 ◽

Cited By ~ 3

Author(s):

C. Rudolphi ◽

G. Blaschke

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Performance ◽

In Vivo Metabolism

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Chronic in vitro fermentation and in vivo metabolism: Extracellular polysaccharides from Sporidiobolus pararoseus regulate the intestinal microbiome of humans and mice

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.09.127 ◽

2021 ◽

Vol 192 ◽

pp. 398-406

Author(s):

Bin Hu ◽

Chang Liu ◽

Wenhao Jiang ◽

Hongkang Zhu ◽

Hui Zhang ◽

...

Keyword(s):

Intestinal Microbiome ◽

Extracellular Polysaccharides ◽

In Vivo Metabolism ◽

In Vitro Fermentation ◽

Sporidiobolus Pararoseus

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Correction: In Vitro and In Vivo Metabolism and Inhibitory Activities of Vasicine, a Potent Acetylcholinesterase and Butyrylcholinesterase Inhibitor

PLoS ONE ◽

10.1371/journal.pone.0129759 ◽

2015 ◽

Vol 10 (6) ◽

pp. e0129759

Author(s):

Keyword(s):

In Vivo Metabolism ◽

Butyrylcholinesterase Inhibitor ◽

Inhibitory Activities

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Effects of phenobarbital and β‐naphthoflavone on the in vivo toxicity and in vitro metabolism of aflatoxin in an aflatoxin‐resistant and control line of chickens

Journal of Toxicology and Environmental Health ◽

10.1080/15287399009531457 ◽

1990 ◽

Vol 31 (4) ◽

pp. 291-311 ◽

Cited By ~ 4

Author(s):

R. O. Manning ◽

R. D. Wyatt ◽

H. L. Marks

Keyword(s):

In Vitro Metabolism ◽

Control Line ◽

In Vivo Toxicity ◽

And Control

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Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole

Drug Metabolism and Disposition ◽

10.1124/dmd.107.018796 ◽

2008 ◽

Vol 36 (7) ◽

pp. 1255-1260 ◽

Cited By ~ 30

Author(s):

Chuang Lu ◽

Panos Hatsis ◽

Cicely Berg ◽

Frank W. Lee ◽

Suresh K. Balani

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Human Hepatocyte ◽

Phenotypic Data ◽

Hepatocyte Suspension ◽

Pharmacokinetic Drug

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Determination of GnRH and its synthetic analogues' abuse in doping control: Small bioactive peptide UPLC-MS/MS method extension by addition of in vitro and in vivo metabolism data; evaluation of LH and steroid profile parameter fluctuations as suitable bi

Drug Testing and Analysis ◽

10.1002/dta.2256 ◽

2017 ◽

Vol 10 (4) ◽

pp. 711-722 ◽

Cited By ~ 3

Author(s):

Irina Zvereva ◽

Grigory Dudko ◽

Marina Dikunets

Keyword(s):

Data Evaluation ◽

Bioactive Peptide ◽

In Vivo Metabolism ◽

Synthetic Analogues ◽

Profile Parameter ◽

In Doping ◽

Steroid Profile

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In vivo and in vitro metabolism of the novel synthetic cannabinoid 5F-APINAC

Forensic Toxicology ◽

10.1007/s11419-019-00503-z ◽

2019 ◽

Vol 38 (1) ◽

pp. 160-171 ◽

Cited By ~ 1

Author(s):

Svetlana A. Appolonova ◽

Covadonga Palacio ◽

Ksenia M. Shestakova ◽

Natalia V. Mesonzhnik ◽

Alex Brito ◽

...

Keyword(s):

Synthetic Cannabinoid ◽

In Vitro Metabolism ◽

The Novel

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