Bone Marrow Chemoprotection without Compromise of Chemotherapy Efficacy in a Rat Brain Tumor Model

2004 ◽  
Vol 309 (2) ◽  
pp. 594-599 ◽  
Author(s):  
Edward A. Neuwelt ◽  
Michael A. Pagel ◽  
Dale F. Kraemer ◽  
Darryl R. Peterson ◽  
Leslie L. Muldoon
Keyword(s):  
Bone Marrow ◽  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Model ◽  
Rat Brain Tumor ◽  
Brain Tumor Model ◽  
Chemotherapy Efficacy

Quantitative Measurements of Regional Glucose Utilization and Rate of Valine Incorporation into Proteins by Double-Tracer Autoradiography in the Rat Brain Tumor Model

1989 ◽  
Vol 9 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Michihiro Kirikae ◽  
Mirko Diksic ◽  
Y. Lucas Yamamoto
Keyword(s):  
Protein Synthesis ◽  
Brain Tumor ◽  
Rat Brain ◽  
Brain Tissue ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Normal Brain ◽  
Normal Brain Tissue ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

We examined the rate of glucose utilization and the rate of valine incorporation into proteins using 2-[18F]fluoro-2-deoxyglucose and L-[1-14C]-valine in a rat brain tumor model by quantitative double-tracer autoradiography. We found that in the implanted tumor the rate of valine incorporation into proteins was about 22 times and the rate of glucose utilization was about 1.5 times that in the contralateral cortex. (In the ipsilateral cortex, the tumor had a profound effect on glucose utilization but no effect on the rate of valine incorporation into proteins.) Our findings suggest that it is more useful to measure protein synthesis than glucose utilization to assess the effectiveness of antitumor agents and their toxicity to normal brain tissue. We compared two methods to estimate the rate of valine incorporation: “kinetic” (quantitation done using an operational equation and the average brain rate coefficients) and “washed slices” (unbound labeled valine removed by washing brain slices in 10% thrichloroacetic acid). The results were the same using either method. It would seem that the kinetic method can thus be used for quantitative measurement of protein synthesis in brain tumors and normal brain tissue using [11C]-valine with positron emission tomography.

Analysis and Distribution of Etoposide in Rat Brain Tumor Model: Intracarotid Versus Intracarotid with Angiotensin II—Induced Hypertension

1993 ◽  
Vol 11 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Hidenori Ogasawara ◽  
Tohru Uozumi ◽  
Katsuzo Kiya ◽  
Kaoru Kurisu ◽  
Takashi Mikami ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Angiotensin Ii ◽  
Rat Brain ◽  
Tumor Model ◽  
Induced Hypertension ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

scholarly journals Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model

Radiology ◽  
2020 ◽  
Vol 294 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Philippe Robert ◽  
Véronique Vives ◽  
Anne-Laure Grindel ◽  
Stéphane Kremer ◽  
Guillaume Bierry ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Contrast Agent ◽  
Rat Brain ◽  
Tumor Model ◽  
Rat Brain Tumor ◽  
Brain Tumor Model ◽  
Relationship Of

scholarly journals Evaluation of (E)-2?-deoxy-2?-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI

2003 ◽  
Vol 16 (2) ◽  
pp. 67-76 ◽  
Author(s):  
Brian D. Ross ◽  
Thomas L. Chenevert ◽  
Michael Garwood ◽  
Boklye Kim ◽  
Lauren D. Stegman ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Model ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

Effect of pentobarbital on normal brain protection and on the response of 9L rat brain tumor to radiation therapy

1993 ◽  
Vol 79 (4) ◽  
pp. 577-583 ◽  
Author(s):  
Bruce F. Kimler ◽  
Changnian Liu ◽  
Richard G. Evans ◽  
Robert A. Morantz
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Model ◽  
Intracranial Tumor ◽  
Normal Brain ◽  
Animal Survival ◽  
Significant Difference ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

✓ The authors attempted to confirm published reports that pentobarbital protects against radiation-induced damage to normal rat brain, as well as enhances radiotherapeutic efficacy in a rat brain tumor model. They evaluated animal survival in 9L gliosarcoma-burdened rats that received whole-brain radiation therapy (16, 24, 32, or 40 Gy) while under intraperitoneal pentobarbital (60 mg/kg) or intramuscular ketamine (60 mg/kg) sedation. The animals were examined at autopsy to attribute death to either intracranial tumor growth or normal brain toxicity in the absence of discernible tumor. There was no difference between the two anesthesia groups regarding the survival of unirradiated animals. Radiation therapy produced a significant dose-dependent prolongation in animal survival, which was limited by the development of normal tissue toxicity at the higher doses. When compared to ketamine anesthesia, pentobarbital anesthesia appeared to offer some protection (not statistically significant) against early (but not late) toxicity at selected radiation doses. A reduction in the number of deaths from tissue toxicity suggested an increased antitumor effect, but again this was not statistically significant. Only in one case was there even a marginal significant difference (p = 0.045) between overall therapeutic efficacy in rats sedated with pentobarbital versus ketamine. While there may be a radioprotective effect of pentobarbital in rat brains without intracranial tumor, there is no conclusive evidence for either radioprotection or significant improvement of radiotherapeutic efficacy in this 9L rat brain tumor model.

Stereotactic Delivery of a Recombinant Adenovirus into a C6 Glioma Cell Line in a Rat Brain Tumor Model

Neurosurgery ◽  
1994 ◽  
Vol 35 (5) ◽  
pp. 910???916 ◽  
Author(s):  
Behnam Badie ◽  
Kelly Hunt ◽  
James S. Economou ◽  
Keith L. Black
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Glioma Cell ◽  
Recombinant Adenovirus ◽  
Tumor Model ◽  
Glioma Cell Line ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

Stereotactic Delivery of a Recombinant Adenovirus into a C6 Glioma Cell Line in a Rat Brain Tumor Model

Neurosurgery ◽  
1994 ◽  
Vol 35 (5) ◽  
pp. 910-916 ◽  
Author(s):  
Behnam Badie ◽  
Kelly Hunt ◽  
James S. Economou ◽  
Keith L. Black
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Glioma Cell ◽  
Recombinant Adenovirus ◽  
Tumor Model ◽  
Glioma Cell Line ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

Combination of radiation therapy and intracranial bleomycin in the 9L rat brain tumor model

1990 ◽  
Vol 18 (5) ◽  
pp. 1115-1121 ◽  
Author(s):  
Bruce F. Kimler ◽  
Douglas F. Martin ◽  
Richard G. Evans ◽  
Robert A. Morantz ◽  
Tribhawan S. Vats
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Model ◽  
Rat Brain Tumor ◽  
Brain Tumor Model
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