Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy

Receptor Ligands ◽

Β2 Adrenergic Receptor ◽

Adrenergic Receptor Ligands

Faculty Opinions recommendation of Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1047914.497938 ◽

2006 ◽

Author(s):

Paul Simpson

Keyword(s):

Protein Kinase ◽

Adenylyl Cyclase ◽

Adrenergic Receptor ◽

Receptor Ligands ◽

Adrenergic Receptor Ligands

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

Journal of Biological Chemistry ◽

10.1074/jbc.274.3.1185 ◽

1999 ◽

Vol 274 (3) ◽

pp. 1185-1188 ◽

Cited By ~ 203

Author(s):

Seungkirl Ahn ◽

Stuart Maudsley ◽

Louis M. Luttrell ◽

Robert J. Lefkowitz ◽

Yehia Daaka

Keyword(s):

Protein Kinase ◽

Tyrosine Phosphorylation ◽

Adrenergic Receptor ◽

Receptor Internalization ◽

Kinase Signaling ◽

Β2 Adrenergic Receptor ◽

Protein Kinase Signaling

Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylation

FEBS Journal ◽

10.1111/j.1742-4658.2011.08459.x ◽

2012 ◽

Vol 279 (4) ◽

pp. 650-660 ◽

Cited By ~ 4

Author(s):

Mohammad Seyedabadi ◽

Seyed Nasser Ostad ◽

Paul R. Albert ◽

Ahmad R. Dehpour ◽

Reza Rahimian ◽

...

Keyword(s):

Protein Kinase ◽

Adenylyl Cyclase ◽

Kinase Phosphorylation

Long-term regulation of signalling components of adenylyl cyclase and mitogen-activated protein kinase in the pre-frontal cortex of human opiate addicts

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2004.02473.x ◽

2004 ◽

Vol 90 (1) ◽

pp. 220-230 ◽

Cited By ~ 38

Author(s):

M. Ferrer-Alcón ◽

M. J. García-Fuster ◽

R La Harpe ◽

J. A. García-Sevilla

Keyword(s):

Protein Kinase ◽

Frontal Cortex ◽

Adenylyl Cyclase ◽

Opiate Addicts

Differential Activation of Mitogen-Activated Protein Kinase Pathways in PC12 Cells by Closely Related α1-Adrenergic Receptor Subtypes

Journal of Neurochemistry ◽

10.1046/j.1471-4159.1999.0722388.x ◽

2002 ◽

Vol 72 (6) ◽

pp. 2388-2396 ◽

Cited By ~ 44

Author(s):

Hongying Zhong ◽

Kenneth P. Minneman

Keyword(s):

Protein Kinase ◽

Pc12 Cells ◽

Adrenergic Receptor ◽

Receptor Subtypes ◽

Differential Activation ◽

Mitogen Activated Protein

Stabilization of the B-type natriuretic peptide mRNA in cardiac myocytes by alpha-adrenergic receptor activation: potential roles for protein kinase C and mitogen-activated protein kinase

Molecular Endocrinology ◽

10.1210/me.10.12.1719 ◽

1996 ◽

Vol 10 (12) ◽

pp. 1719-1727 ◽

Cited By ~ 17

Author(s):

D. S. Hanford

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Cardiac Myocytes ◽

Natriuretic Peptide ◽

Adrenergic Receptor ◽

Receptor Activation ◽

Alpha Adrenergic Receptor ◽

Kinase C ◽

Mitogen Activated Protein

Faculty Opinions recommendation of Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116225.576106 ◽

2008 ◽

Author(s):

Andrew Tobin

Keyword(s):

Protein Kinase ◽

Adrenergic Receptor ◽

Signaling Cascades ◽

Kinase Signaling ◽

Conformational Rearrangements ◽

Protein Kinase Signaling

Faculty Opinions recommendation of Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116225.572223 ◽

2008 ◽

Author(s):

Ralf Jockers ◽

Maud Kamal

Keyword(s):

Protein Kinase ◽

Adrenergic Receptor ◽

Signaling Cascades ◽

Kinase Signaling ◽

Conformational Rearrangements ◽

Protein Kinase Signaling

The β3-Adrenergic Receptor Activates Mitogen-activated Protein Kinase in Adipocytes through a Gi-dependent Mechanism

Journal of Biological Chemistry ◽

10.1074/jbc.274.17.12017 ◽

1999 ◽

Vol 274 (17) ◽

pp. 12017-12022 ◽

Cited By ~ 137

Author(s):

Kurt J. Soeder ◽

Sheridan K. Snedden ◽

Wenhong Cao ◽

Gregory J. Della Rocca ◽

Kiefer W. Daniel ◽

...

Keyword(s):

Protein Kinase ◽

Adrenergic Receptor ◽

Dependent Mechanism

Search for β2 Adrenergic Receptor Ligands by Virtual Screening via Grid Computing and Investigation of Binding Modes by Docking and Molecular Dynamics Simulations

PLoS ONE ◽

10.1371/journal.pone.0107837 ◽

2014 ◽

Vol 9 (9) ◽

pp. e107837 ◽

Cited By ~ 6

Author(s):

Qifeng Bai ◽

Yonghua Shao ◽

Dabo Pan ◽

Yang Zhang ◽

Huanxiang Liu ◽

...

Keyword(s):

Molecular Dynamics ◽

Virtual Screening ◽

Grid Computing ◽

Molecular Dynamics Simulations ◽

Adrenergic Receptor ◽

Binding Modes ◽

Receptor Ligands ◽

Β2 Adrenergic Receptor ◽

Dynamics Simulations ◽

Adrenergic Receptor Ligands