Estrogen Receptors and Type 1 Metabotropic Glutamate Receptors Are Interdependent in Protecting Cortical Neurons against β-Amyloid Toxicity

2011 ◽  
Vol 81 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Simona Federica Spampinato ◽  
Gemma Molinaro ◽  
Sara Merlo ◽  
Luisa Iacovelli ◽  
Filippo Caraci ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Glutamate Receptors ◽  
Cortical Neurons ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Amyloid Toxicity ◽  
Β Amyloid

β-Amyloid Peptides Impair PKC-Dependent Functions of Metabotropic Glutamate Receptors in Prefrontal Cortical Neurons

2005 ◽  
Vol 93 (6) ◽  
pp. 3102-3111 ◽  
Author(s):  
Joanna P. Tyszkiewicz ◽  
Zhen Yan
Keyword(s):  
Nmda Receptor ◽  
Glutamate Receptors ◽  
Cortical Neurons ◽  
Metabotropic Glutamate Receptors ◽  
Pyramidal Neurons ◽  
Amyloid Peptide ◽  
Metabotropic Glutamate ◽  
Prefrontal Cortical ◽  
Group I ◽  
Β Amyloid

The metabotropic glutamate receptors (mGluRs) have been implicated in cognition, memory, and some neurodegenerative disorders, including the Alzheimer's disease (AD). To understand how the dysfunction of mGluRs contributes to the pathophysiology of AD, we examined the β-amyloid peptide (Aβ)-induced alterations in the physiological functions of mGluRs in prefrontal cortical pyramidal neurons. Two potential targets of mGluR signaling involved in cognition, the GABAergic system and the N-methyl-d-aspartate (NMDA) receptor, were examined. Activation of group I mGluRs with (S)-3,5-dihydroxyphenylglycine (DHPG) significantly increased the spontaneous inhibitory postsynaptic current (sIPSC) amplitude, and this effect was protein kinase C (PKC) sensitive. Treatment with Aβ abolished the DHPG-induced enhancement of sIPSC amplitude. On the other hand, activation of group II mGluRs with (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC) significantly increased the NMDA receptor (NMDAR)-mediated currents via a PKC-dependent mechanism, and Aβ treatment also diminished the APDC-induced potentiation of NMDAR currents. In Aβ-treated slices, both DHPG and APDC failed to activate PKC. These results indicate that the mGluR regulation of GABA transmission and NMDAR currents is impaired by Aβ treatment probably due to the Aβ-mediated interference of mGluR activation of PKC. This study provides a framework within which the role of mGluRs in normal cognitive functions and AD can be better understood.

scholarly journals Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

2018 ◽  
Vol 104 ◽  
pp. 130-137 ◽  
Author(s):  
Katherine R. Tonn Eisinger ◽  
Kellie S. Gross ◽  
Brian P. Head ◽  
Paul G. Mermelstein
Keyword(s):  
Estrogen Receptors ◽  
Glutamate Receptors ◽  
Drug Addiction ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

2015 ◽  
Vol 41 (4) ◽  
pp. 924-932 ◽  
Author(s):  
Maria Rosaria Romano ◽  
Luisa Di Menna ◽  
Pamela Scarselli ◽  
Giada Mascio ◽  
Michele Madonna ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

Relationship between type 1 metabotropic glutamate receptors and cerebellar ataxia

2016 ◽  
Vol 263 (11) ◽  
pp. 2179-2187 ◽  
Author(s):  
Kenji Ishibashi ◽  
Yoshiharu Miura ◽  
Kinya Ishikawa ◽  
Ming-Rong Zhang ◽  
Jun Toyohara ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Cerebellar Ataxia ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate
Sign in / Sign up

Export Citation Format

Share Document