Apolipoprotein B mRNA Editing and the Reduction in Synthesis and Secretion of the Atherogenic Risk Factor, Apolipoprotein B100 Can Be Effectively Targeted through TAT-Mediated Protein Transduction

2002 ◽  
Vol 61 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Yan Yang ◽  
Nazzareno Ballatori ◽  
Harold C. Smith
Keyword(s):  
Risk Factor ◽  
Apolipoprotein B ◽  
Protein Transduction ◽  
Mrna Editing ◽  
Apolipoprotein B100

Increased hepatic synthesis and accumulation of plasma apolipoprotein B100 in copper-deficient rats does not result from modification in apolipoprotein B mRNA editing

Lipids ◽  
1996 ◽  
Vol 31 (4) ◽  
pp. 433-436 ◽  
Author(s):  
Fatiha Nassir ◽  
Federico Giannoni ◽  
Andrzej Mazur ◽  
Yves Rayssiguier ◽  
Nicholas O. Davidson
Keyword(s):  
Apolipoprotein B ◽  
Mrna Editing ◽  
Apolipoprotein B100 ◽  
Hepatic Synthesis ◽  
Plasma Apolipoprotein

scholarly journals Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development

2020 ◽  
Vol 10 (23) ◽  
pp. 8681
Author(s):  
Manabu Niimi ◽  
Yajie Chen ◽  
Haizhao Yan ◽  
Yao Wang ◽  
Tomonari Koike ◽  
...  
Keyword(s):  
Risk Factor ◽  
Drug Development ◽  
Apolipoprotein B ◽  
Molecular Mechanisms ◽  
Lipoprotein Metabolism ◽  
Mrna Editing ◽  
Experimental Animals ◽  
Transfer Protein ◽  
Hyperlipidemic Rabbit ◽  
Plasma Apolipoprotein

Hyperlipidemia or dyslipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are one of the most suitable models to study human hyperlipidemia because many features of the lipoprotein metabolism of rabbits are similar to those of humans such as LDL-rich lipoproteins in plasma, apolipoprotein B mRNA editing, and cholesteryl ester transfer protein. Currently, three types of rabbit models are commonly used for studying hyperlipidemia: (1) diet-induced hyperlipidemic rabbits, (2) spontaneous hyperlipidemic rabbits, and (3) gene-manipulated rabbits (transgenic and knockout rabbits). In this review, we give an overview of the features of hyperlipidemic rabbits and discuss the usefulness of rabbits for the development of anti-atherogenic drugs.

scholarly journals Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): structure–function relationships of RNA editing and dimerization

1999 ◽  
Vol 40 (4) ◽  
pp. 623-635 ◽  
Author(s):  
Ba-Bie Teng ◽  
Scott Ochsner ◽  
Qian Zhang ◽  
Kizhake V. Soman ◽  
Paul P. Lau ◽  
...  
Keyword(s):  
Structure Function ◽  
Rna Editing ◽  
Apolipoprotein B ◽  
Mutational Analysis ◽  
Mrna Editing ◽  
Editing Enzyme

scholarly journals Apolipoprotein B mRNA editing. Direct determination of the edited base and occurrence in non-apolipoprotein B-producing cell lines.

1990 ◽  
Vol 265 (36) ◽  
pp. 22446-22452 ◽  
Author(s):  
K Boström ◽  
Z Garcia ◽  
K S Poksay ◽  
D F Johnson ◽  
A J Lusis ◽  
...  
Keyword(s):  
Cell Lines ◽  
Apolipoprotein B ◽  
Direct Determination ◽  
Mrna Editing

Apolipoprotein B mRNA Editing

2018 ◽  
pp. 297-317
Author(s):  
Nicholas O. Davidson
Keyword(s):  
Apolipoprotein B ◽  
Mrna Editing
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