MARKING ANOPHELES MOSQUITOES WITH FLUORESCENT COMPOUNDS

Science ◽  
1945 ◽  
Vol 102 (2641) ◽  
pp. 157-157 ◽  
Author(s):  
J. W. ZUKEL
2002 ◽  
Vol 15 (6) ◽  
pp. 449-453 ◽  
Author(s):  
G. Grygierczyk ◽  
Walter Fischer ◽  
M. Sajewicz ◽  
P. Kuś ◽  
R. Wrzalik ◽  
...  

2020 ◽  
Author(s):  
Sofia Alexandra Milheiro ◽  
Joana Gonçalves ◽  
Ricardo Lopes ◽  
Margarida Madureira ◽  
Lis Lobo ◽  
...  

<p><a>A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds of general formula [(</a>η<sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Ru(PPh<sub>3</sub>)(N-N)][PF<sub>6</sub>], a scaffold hitherto unfeatured in the toolbox of antiplasmodials, was screened for activity against the blood stage of CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 <i>Plasmodium falciparum</i> strains, and the liver stage of <i>P. berghei</i>. The best performing compounds displayed dual-stage activity, with single-digit nM IC<sub>50</sub> values against blood stage malaria parasites, nM activity against liver stage parasites, and residual cytotoxicity against mammalian cells (HepG2, Huh7). Parasitic absorption/distribution of 7-nitrobenzoxadiazole-appended fluorescent compounds <b>Ru4</b> and <b>Ru5</b> was investigated by confocal fluorescence microscopy, revealing parasite-selective absorption in infected erythrocytes and nuclear accumulation of both compounds. The lead compound <b>Ru2</b> impaired asexual parasite differentiation, exhibiting fast parasiticidal activity against both ring and trophozoite stages of a synchronized <i>P. falciparum</i> 3D7 strain. These results point to cyclopentadienylruthenium(II) complexes as a highly promising chemotype for the development of dual-stage antiplasmodials.</p>


1947 ◽  
Vol 20 (2) ◽  
pp. 146-160 ◽  
Author(s):  
Joseph Hall Bodine ◽  
Laurence R. Fitzgerald

1995 ◽  
Vol 32 (3) ◽  
pp. 300-305 ◽  
Author(s):  
Claudia F. Golenda ◽  
Terry Klein ◽  
Russel Coleman ◽  
Robert Burge ◽  
Ronald A. Ward ◽  
...  

1997 ◽  
Vol 91 (sup1) ◽  
pp. S117-S118 ◽  
Author(s):  
B. G. J. Knols ◽  
W. Takken ◽  
A. Cork ◽  
R. De Jong

2011 ◽  
Vol 295-297 ◽  
pp. 813-816 ◽  
Author(s):  
Li Liu

Silicon dioxide-based nanocomposites offer large loading capacity for various doping chemicals or molecular complexes, high surface to volume ratio and customizable surface chemistry for the creation and development of novel sensors and devices [1-2]. When compared with other sol-gel materials, xerogels represent a class of nanocomposites that are relatively easy to fabricate but with unique thermal, acoustic, optical and mechanical properties for rapid sensor or device prototyping development [3-4]. Xerogels in solids are formed by controlled evaporation of the liquid in the hydro-gel. Their porosity and morphology depend largely on the temperature, gel chemical compositions and pH in the fabrication process. When impregnated with fluorescent compounds in their nanosize cavities, the doped xerogels exhibit strong and stable fluorescence properties that are useful for the developing of ion-exchange sensors and optical devices. However, the use of these fluorescently doped xerogels in forensic applications was still largely unexplored.


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