Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Science ◽  
2003 ◽  
Vol 301 (5638) ◽  
pp. 1387-1391 ◽  
Author(s):  
A. Melendez
Keyword(s):  
Life Span ◽  
Life Span Extension ◽  
C Elegans

scholarly journals The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations

2020 ◽  
Author(s):  
Anita Goyala ◽  
Aiswarya Baruah ◽  
Arnab Mukhopadhyay
Keyword(s):  
Life Span ◽  
Dietary Restriction ◽  
Model Systems ◽  
Regulation Of Expression ◽  
Life Span Extension ◽  
Phenotypic Differences ◽  
C Elegans ◽  
Xenobiotic Detoxification ◽  
Organismal Biology ◽  
Extend Life Span

AbstractDietary restriction (DR) increases life span and improves health in most model systems tested, including non-human primates. In C. elegans, as in other models, DR leads to reprogramming of metabolism, improvements in mitochondrial health, large changes in gene expression, including increase in expression of cytoprotective genes, better proteostasis etc. Understandably, multiple global transcriptional regulators like transcription factors FOXO/DAF-16, FOXA/PHA-4, HSF1/HSF-1 and NRF2/SKN-1 are important for DR longevity. Considering the wide-ranging effects of p53 on organismal biology, we asked whether the C. elegans ortholog, CEP-1 is required for DR-mediated longevity assurance. We employed the widely-used TJ1 strain of cep-1(gk138). We show that cep-1(gk138) suppresses the life span extension of two genetic paradigms of DR, but two non-genetic modes of DR remain unaffected in this strain. We find that in cep-1(gk138), two aspects of DR, increased autophagy and the up-regulation of expression of cytoprotective xenobiotic detoxification program (cXDP) genes are dampened. Importantly, we find that background mutation(s) in the strain may be the actual cause for the phenotypic differences that we observed and cep-1 may not be directly involved in genetic DR-mediated longevity assurance in worms. Identifying these mutation(s) may reveal a novel regulator of longevity required specifically by genetic modes of DR.

scholarly journals Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

2011 ◽  
Vol 14 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Aric N. Rogers ◽  
Di Chen ◽  
Gawain McColl ◽  
Gregg Czerwieniec ◽  
Krysta Felkey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stress Response ◽  
Life Span ◽  
Response Gene ◽  
Life Span Extension ◽  
C Elegans ◽  
Stress Response Gene

scholarly journals The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241478
Author(s):  
Anita Goyala ◽  
Aiswarya Baruah ◽  
Arnab Mukhopadhyay
Keyword(s):  
Life Span ◽  
Dietary Restriction ◽  
Transcriptional Regulators ◽  
Model Systems ◽  
Life Span Extension ◽  
Phenotypic Differences ◽  
C Elegans ◽  
Xenobiotic Detoxification ◽  
Organismal Biology ◽  
Extend Life Span

Dietary restriction (DR) increases life span and improves health in most model systems tested, including non-human primates. In C. elegans, as in other models, DR leads to reprogramming of metabolism, improvements in mitochondrial health, large changes in expression of cytoprotective genes and better proteostasis. Understandably, multiple global transcriptional regulators like transcription factors FOXO/DAF-16, FOXA/PHA-4, HSF1/HSF-1 and NRF2/SKN-1 are important for DR longevity. Considering the wide-ranging effects of p53 on organismal biology, we asked whether the C. elegans ortholog, CEP-1 is required for DR-mediated longevity assurance. We employed the widely-used TJ1 strain of cep-1(gk138). We show that cep-1(gk138) suppresses the life span extension of two genetic paradigms of DR, but two non-genetic modes of DR remain unaffected in this strain. We find that two aspects of DR, increased autophagy and up-regulation of the expression of cytoprotective xenobiotic detoxification program (cXDP) genes, are dampened in cep-1(gk138). Importantly, we find that background mutation(s) in the strain may be the actual cause for the phenotypic differences that we observed and cep-1 may not be directly involved in genetic DR-mediated longevity assurance in worms. Identifying these mutation(s) may reveal a novel regulator of longevity required specifically by genetic modes of DR.

scholarly journals Reductive stress on life span extension in C. elegans

2008 ◽  
Vol 1 (1) ◽  
pp. 19 ◽  
Author(s):  
Markus Ralser ◽  
Ivor J Benjamin
Keyword(s):  
Life Span ◽  
Life Span Extension ◽  
C Elegans ◽  
Reductive Stress

scholarly journals Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans

Science ◽  
2020 ◽  
Vol 367 (6476) ◽  
pp. 436-440 ◽  
Author(s):  
Ashley E. Frakes ◽  
Melissa G. Metcalf ◽  
Sarah U. Tronnes ◽  
Raz Bar-Ziv ◽  
Jenni Durieux ◽  
...  
Keyword(s):  
Er Stress ◽  
Life Span ◽  
Glial Cells ◽  
Stress Responses ◽  
Stress Resistance ◽  
Life Span Extension ◽  
C Elegans ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

The ability of the nervous system to sense cellular stress and coordinate protein homeostasis is essential for organismal health. Unfortunately, stress responses that mitigate disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (UPRER), become defunct with age. In this work, we expressed the constitutively active UPRER transcription factor, XBP-1s, in a subset of astrocyte-like glia, which extended the life span in Caenorhabditis elegans. Glial XBP-1s initiated a robust cell nonautonomous activation of the UPRER in distal cells and rendered animals more resistant to protein aggregation and chronic ER stress. Mutants deficient in neuropeptide processing and secretion suppressed glial cell nonautonomous induction of the UPRER and life-span extension. Thus, astrocyte-like glial cells play a role in regulating organismal ER stress resistance and longevity.

scholarly journals Life‐span extension by dietary restriction is mediated by NLP‐7 signaling and coelomocyte endocytosis in C. elegans

2009 ◽  
Vol 24 (2) ◽  
pp. 383-392 ◽  
Author(s):  
Sang‐Kyu Park ◽  
Christopher D. Link ◽  
Thomas E. Johnson
Keyword(s):  
Life Span ◽  
Dietary Restriction ◽  
Life Span Extension ◽  
C Elegans
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