Faculty Opinions recommendation of The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth Helicoverpa armigera, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as evidenced by the facts that Akt, p-Akt, and PRMT1 are elevated by ROS, but not insulin, and that high levels of p-Akt fail to phosphorylate FoxO through PRMT1-mediated methylation. These results suggest a distinct signaling pathway culminating in the elevation of FoxO, which in turn promotes the extension of life span characteristic of diapause.

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Faculty Opinions recommendation of Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031392.365635 ◽

2006 ◽

Author(s):

Daniel Klionsky

Keyword(s):

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Signaling Pathway

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The potential antioxidant ability of hydroxytyrosol on Caenorhabditis elegans against oxidative damage via the insulin signaling pathway

Arabian Journal of Chemistry ◽

10.1016/j.arabjc.2021.103149 ◽

2021 ◽

Vol 14 (6) ◽

pp. 103149

Author(s):

Yujie Wang ◽

Siyuan Luo ◽

Zhou Xu ◽

Li Liu ◽

Shiling Feng ◽

...

Keyword(s):

Caenorhabditis Elegans ◽

Oxidative Damage ◽

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Signaling Pathway ◽

Antioxidant Ability

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Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol

Nutrients ◽

10.3390/nu13072268 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2268

Author(s):

Dina Medina-Vera ◽

Juan Antonio Navarro ◽

Rubén Tovar ◽

Cristina Rosell-Valle ◽

Alfonso Gutiérrez-Adan ◽

...

Keyword(s):

Oral Administration ◽

Signaling Pathway ◽

Insulin Signaling ◽

Insulin Response ◽

Pharmacological Action ◽

Akt Signaling ◽

Insulin Signaling Pathway ◽

Acute Administration ◽

Insulin Sensitizer ◽

Peripheral Tissues

D-Pinitol (DPIN) is a natural occurring inositol capable of activating the insulin pathway in peripheral tissues, whereas this has not been thoroughly studied in the central nervous system. The present study assessed the potential regulatory effects of DPIN on the hypothalamic insulin signaling pathway. To this end we investigated the Phosphatidylinositol-3-kinase (PI3K)/Protein Kinase B (Akt) signaling cascade in a rat model following oral administration of DPIN. The PI3K/Akt-associated proteins were quantified by Western blot in terms of phosphorylation and total expression. Results indicate that the acute administration of DPIN induced time-dependent phosphorylation of PI3K/Akt and its related substrates within the hypothalamus, indicating an activation of the insulin signaling pathway. This profile is consistent with DPIN as an insulin sensitizer since we also found a decrease in the circulating concentration of this hormone. Overall, the present study shows the pharmacological action of DPIN in the hypothalamus through the PI3K/Akt pathway when giving in fasted animals. These findings suggest that DPIN might be a candidate to treat brain insulin-resistance associated disorders by activating insulin response beyond the insulin receptor.

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