Infection of normal human epithelial cells by Epstein-Barr virus

Science ◽  
1983 ◽  
Vol 219 (4589) ◽  
pp. 1225-1228 ◽  
Author(s):  
I. Shapiro ◽  
D. Volsky
Keyword(s):  
Epithelial Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Normal Human ◽  
Epstein Barr

CD40 signaling activated by Epstein–Barr virus promotes cell survival and proliferation in gastric carcinoma-derived human epithelial cells

2009 ◽  
Vol 11 (3) ◽  
pp. 429-433 ◽  
Author(s):  
Ken-Ichi Imadome ◽  
Norio Shimizu ◽  
Misako Yajima ◽  
Ken Watanabe ◽  
Hiroyuki Nakamura ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Gastric Carcinoma ◽  
Cell Survival ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Epstein Barr ◽  
Cell Survival And Proliferation

scholarly journals Epstein–Barr Virus DNase (BGLF5) induces genomic instability in human epithelial cells

2009 ◽  
Vol 38 (6) ◽  
pp. 1932-1949 ◽  
Author(s):  
Chung-Chun Wu ◽  
Ming-Tsan Liu ◽  
Yu-Ting Chang ◽  
Chih-Yeu Fang ◽  
Sheng-Ping Chou ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Genomic Instability ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Epstein Barr

scholarly journals Identification of Functional Differences between Prototype Epstein–Barr Virus-Encoded LMP1 and a Nasopharyngeal Carcinoma-Derived LMP1 in Human Epithelial Cells

Virology ◽  
2000 ◽  
Vol 272 (1) ◽  
pp. 204-217 ◽  
Author(s):  
Christopher W. Dawson ◽  
Aristides G. Eliopoulos ◽  
Sarah M. Blake ◽  
Rachel Barker ◽  
Lawrence S. Young
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Functional Differences ◽  
Human Epithelial Cells ◽  
Epstein Barr

scholarly journals Epstein-Barr virus latent membrane protein does not inhibit differentiation and induces tumorigenicity of human epithelial cells

Oncogene ◽  
1997 ◽  
Vol 15 (3) ◽  
pp. 275-283 ◽  
Author(s):  
L J Nicholson ◽  
P Hopwood ◽  
I Johannessen ◽  
J R Salisbury ◽  
J Codd ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

scholarly journals Characterization of an Epstein-Barr virus receptor on human epithelial cells.

1992 ◽  
Vol 176 (5) ◽  
pp. 1405-1414 ◽  
Author(s):  
M Birkenbach ◽  
X Tong ◽  
L E Bradbury ◽  
T F Tedder ◽  
E Kieff
Keyword(s):  
Epithelial Cell ◽  
Epithelial Cells ◽  
Epstein Barr Virus ◽  
B Lymphocyte ◽  
Viral Envelope ◽  
Epithelial Cell Line ◽  
Epithelial Tissue ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Epstein Barr

Epstein-Barr virus (EBV) adsorption to human B lymphocytes is mediated by the viral envelope glycoprotein, gp350/220, which binds to the cell surface protein, CD21, also known as the CR2 complement receptor. Human epithelial cells also express an EBV receptor. A candidate surface molecule of 195 kD has previously been identified on an epithelial cell line and explanted epithelial tissue by reactivity with the CD21 specific monoclonal antibody (mAb), HB-5a. In experiments to further characterize the epithelial cell EBV receptor, we have found that two human epithelial cell lines, RHEK-1 and HeLa, specifically bind intact EB virions. A 145-kD protein, similar in size to B lymphocyte CD21, was specifically precipitated from surface iodinated RHEK-1 cells using the HB-5a mAb, or using purified soluble gp350/220 coupled to agarose beads. The previously identified 195-kD protein did not bind to gp350/220 or react with two other anti-CD21 mAbs. CD21 homologous RNA, similar in size to the B lymphocyte CD21 mRNA, was detected in both RHEK-1 and HeLa cells. The nucleotide sequence of the epithelial cell cDNA was identical to B lymphocyte CD21. The longest clone differs from previously reported CD21 cDNAs in having additional 5' untranslated sequence. Polymerase chain reaction amplification of RHEK-1- or B lymphoblastoid-derived cDNA verified that most CD21 transcripts are initiated at least 30-50 nucleotides upstream of the previously reported mRNA cap site. These experiments demonstrate that human epithelial cells can express CD21, and that CD21 is likely to mediate EBV adsorption to epithelial cells.

Identification of a Promoter for the Latent Membrane Protein 1 Gene of Epstein-Barr Virus That Is Specifically Activated in Human Epithelial Cells

1997 ◽  
Vol 16 (7) ◽  
pp. 829-837 ◽  
Author(s):  
MENG-HSIUNG CHANG ◽  
CHENG-KOON NG ◽  
YU-JUNG LIN ◽  
CHIH-LUNG LIANG ◽  
PEI-JUNG CHUNG ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Epstein Barr

Infection of human epithelial cells by Epstein-Barr Virus (EBV)

1985 ◽  
Vol 3 (3) ◽  
pp. 207-212
Author(s):  
Faruk Sinangil ◽  
Barbara Volsky ◽  
David J. Volsky
Keyword(s):  
Epithelial Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Human Epithelial Cells ◽  
Epstein Barr
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