scholarly journals Response to Comment on “Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior”

Science ◽  
2021 ◽  
Vol 371 (6536) ◽  
pp. eaba5693
Author(s):  
Andrea Ganna ◽  
Karin J. H. Verweij ◽  
Michel G. Nivard ◽  
Robert Maier ◽  
Robbee Wedow ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Genetic Architecture ◽  
Large Scale ◽  
Human Sexuality ◽  
Genetic Influences ◽  
Same Sex ◽  
Main Variable ◽  
Sex Partner

Hamer et al. argue that the variable “ever versus never had a same-sex partner” does not capture the complexity of human sexuality. We agree and said so in our paper. But Hamer et al. neglect to mention that we also reported follow-up analyses showing substantial overlap of the genetic influences on our main variable and on more nuanced measures of sexual behavior, attraction, and identity.

scholarly journals Comment on “Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior”

Science ◽  
2021 ◽  
Vol 371 (6536) ◽  
pp. eaba2941
Author(s):  
Dean Hamer ◽  
Brian Mustanski ◽  
Randall Sell ◽  
Stephanie A. Sanders ◽  
Justin R. Garcia
Keyword(s):  
Sexual Behavior ◽  
Personality Traits ◽  
Sexual Behaviors ◽  
Genetic Architecture ◽  
Large Scale ◽  
Human Sexuality ◽  
Research Articles ◽  
Same Sex ◽  
Full Spectrum ◽  
Sex Partner

The phenotypic measures used by Ganna et al. (Research Articles, 30 August 2019, p. 882) lump together predominantly heterosexual, bisexual, and homosexual individuals, including those who have experimented with a same-sex partner only once. This may have resulted in misleading associations to personality traits unrelated to understood categories of human sexuality. Scientific studies of human sexuality should use validated and reliable measures of sexual behaviors, attractions, and identities that capture the full spectrum of complexity.

scholarly journals Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

Science ◽  
2019 ◽  
Vol 365 (6456) ◽  
pp. eaat7693 ◽  
Author(s):  
Andrea Ganna ◽  
Karin J. H. Verweij ◽  
Michel G. Nivard ◽  
Robert Maier ◽  
Robbee Wedow ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Genetic Architecture ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Same Sex ◽  
Genome Wide ◽  
A Genome ◽  
Number Of Sexual Partners ◽  
Opposite Sex ◽  
Males And Females

Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual’s sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.

scholarly journals Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

2020 ◽  
Author(s):  
Ganna A ◽  
Verweij KJH ◽  
Nivard MG ◽  
Maier R ◽  
Wedow R ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Genetic Architecture ◽  
Large Scale ◽  
Same Sex

scholarly journals Is Men's Heterosexuality Perceived as More Precarious than Women's? An Intersectional, Race-by-Gender Analysis

2021 ◽  
Author(s):  
Christopher D Petsko ◽  
Tony Silva ◽  
Stefan Vogler
Keyword(s):  
United States ◽  
Sexual Behavior ◽  
Large Scale ◽  
The United States ◽  
Target Person ◽  
Gender Analysis ◽  
Same Sex ◽  
Nationally Representative

In the United States, people perceive men’s masculinity to be more precarious, or easier to lose, than women’s femininity. In the present manuscript, we investigated (1) whether men’s heterosexuality is likewise perceived to be more precarious than women’s, and if so, (2) whether this effect is exaggerated when the targets in question are Black rather than White. To investigate these questions, we conducted a large-scale (N = 3,010), nationally representative experiment in which participants read about a target person who either did or did not engage in a single same-sex sexual behavior. Results revealed that participants questioned the heterosexuality of men more than the heterosexuality of women when they engaged (vs. did not engage) in a same-sex sexual behavior. Surprisingly, these effects were not moderated by whether targets were Black vs. White. In other words, men’s heterosexuality was indeed perceived to be more precarious than women’s, irrespective of targets’ race.

scholarly journals A Decade of Stability and Change: Review of U.S. Adolescents' Sexual Behavior and Contraceptive Use 2006-2017

2020 ◽  
Author(s):  
Laura Lindberg ◽  
Lauren Firestein ◽  
Cynthia Beavin
Keyword(s):  
Sexual Behavior ◽  
Sexual Behaviors ◽  
Contraceptive Use ◽  
Sexual Experience ◽  
Adolescent Females ◽  
Same Sex ◽  
Stability And Change ◽  
Changes Over Time ◽  
Over Time ◽  
Sex Partner

This study examines changes over time, and demographic differentials, in the prevalence of select sexual behaviors and contraceptive use measures in a national sample of US adolescents. We used data on female and male adolescents aged 15-19 from the 2006-2010 (N=4,662), 2011-2015 (N=4,134), and 2015-2017 (N=1,810) National Survey of Family Growth. Logistic regression was used to identify differences between periods by gender, and for some measures by age, in sexual behaviors (penile-vaginal intercourse (PVI), oral or anal sex with an opposite-sex partner, sexual experience with a same-sex partner), contraceptive use and condom consistency. We estimated probabilities of age at first PVI with Kaplan-Meier failure analysis and tested for changes over time and differences by gender. Over half of all adolescents have engaged in at least one of the sexual behaviors measured. Between 2011-2015 and 2015-2017, males age 15-17 reported significant declines in all but same-sex partners, while the prevalence of sexual behaviors among older males and adolescent females overall remained generally stable. In each period, females were more likely than males to report a same-sex partner. Age of first PVI increased, but by age 17 the difference between time periods is minimal. Adolescent females report increases in the use at last sex of long-acting reversible contraceptive methods (3% to 18%) and multiple methods (27% to 41%). The condom use measures did not change over time. These findings identify components of both stability and change in adolescent sexual and contraceptive behavior in the last decade. Implications This analysis contributes a timely update on trends in adolescent sexual behavior and contraceptive use, showing that adolescents’ behaviors are complex and evolving. Sexual health information and services must be available so that young people have the resources to make healthy and responsible choices for themselves and their partners.

Three-Year Follow-Up of Couples With Same-Sex Civil Unions

2006 ◽  
Author(s):  
Esther D. Rothblum ◽  
Kimberly F. Balsam
Keyword(s):  
Same Sex ◽  
Civil Unions

Therapy of post-stroke depression – a systematic review

2013 ◽  
Vol 10 (02) ◽  
pp. 108-129 ◽  
Author(s):  
W. Gaebel ◽  
W. Wannagat ◽  
J. Zielasek
Keyword(s):  
Systematic Review ◽  
Large Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Control ◽  
Post Stroke ◽  
Pharmacological Studies ◽  
Post Stroke Depression ◽  
Control Procedures ◽  
Antidepressant Pharmacotherapy

SummaryWe performed a systematic review of randomized placebo-controlled pharmacological and non-pharmacological trials for the therapy and prevention of post-stroke depression that have been published between 1980 and 2011. We initially identified 2 260 records of which 28 studies were finally included into this review. A meta-analytic approach was hampered by considerable differences regarding the kinds of therapeutic regimens and the study durations. Modest effects favoring treatment of post-stroke depression could be found for pharmacological treatment as well as repetitive transcranial magnetic stimulation. For the prevention of post-stroke depression, antidepressant pharmacotherapy showed promising results. However, large-scale studies with better standardized study populations, optimized placebo control procedures in non-pharmacological studies, and replication in larger follow-up studies are still necessary to find the optimal therapeutic regimens to prevent and treat post-stroke depression.

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