Mycobacterium tuberculosis Serine/Threonine Protein Kinases

2015 ◽  
pp. 681-708
Author(s):  
Sladjana Prisic ◽  
Robert N. Husson
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases

scholarly journals Phosphorylation of Mitogen-Activated Protein Kinases Contributes to Interferon γ Production in Response to Mycobacterium tuberculosis

2012 ◽  
Vol 207 (2) ◽  
pp. 340-350 ◽  
Author(s):  
Virginia Pasquinelli ◽  
Ana I. Rovetta ◽  
Ivana B. Alvarez ◽  
Javier O. Jurado ◽  
Rosa M. Musella ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Interferon Γ ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals Interleukin-8 Secretion from Mycobacterium tuberculosis-Infected Monocytes Is Regulated by Protein Tyrosine Kinases but Not by ERK1/2 or p38 Mitogen-Activated Protein Kinases

2002 ◽  
Vol 70 (8) ◽  
pp. 4743-4746 ◽  
Author(s):  
Clara Ameixa ◽  
Jon S. Friedland
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Tyrosine Kinases ◽  
Nuclear Translocation ◽  
Interleukin 8 ◽  
Protein Tyrosine Kinases ◽  
Human Monocytes ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Posttranscriptional Processing

ABSTRACT Mycobacterium tuberculosis upregulates NF-κB binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes. Inhibition of tyrosine protein kinases but not of ERK1/2 or p38 mitogen-activated protein kinases downregulates tuberculosis-induced IL-8 secretion. The inhibitor genistein decreased NF-κB nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.

scholarly journals The Mycobacterium tuberculosis GroEL1 Chaperone Is a Substrate of Ser/Thr Protein Kinases

2009 ◽  
Vol 191 (8) ◽  
pp. 2876-2883 ◽  
Author(s):  
Marc J. Canova ◽  
Laurent Kremer ◽  
Virginie Molle
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Mycobacterium Smegmatis ◽  
Biological Functions

ABSTRACT We demonstrate that Mycobacterium tuberculosis GroEL1 is phosphorylated by PknF at two positions, Thr25 and Thr54. Unexpectedly, Mycobacterium smegmatis GroEL1 is not a substrate of its cognate PknF. This study shows that the phosphorylation profiles of conserved proteins are species dependent and provide insights that may explain the numerous biological functions of these important proteins.

scholarly journals HupB, a Nucleoid-Associated Protein of Mycobacterium tuberculosis, Is Modified by Serine/Threonine Protein Kinases In Vivo

2014 ◽  
Vol 196 (14) ◽  
pp. 2646-2657 ◽  
Author(s):  
M. Gupta ◽  
A. Sajid ◽  
K. Sharma ◽  
S. Ghosh ◽  
G. Arora ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases
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