scholarly journals Phosphorylation of Mitogen-Activated Protein Kinases Contributes to Interferon γ Production in Response to Mycobacterium tuberculosis

2012 ◽  
Vol 207 (2) ◽  
pp. 340-350 ◽  
Author(s):  
Virginia Pasquinelli ◽  
Ana I. Rovetta ◽  
Ivana B. Alvarez ◽  
Javier O. Jurado ◽  
Rosa M. Musella ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Interferon Γ ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals Interleukin-8 Secretion from Mycobacterium tuberculosis-Infected Monocytes Is Regulated by Protein Tyrosine Kinases but Not by ERK1/2 or p38 Mitogen-Activated Protein Kinases

2002 ◽  
Vol 70 (8) ◽  
pp. 4743-4746 ◽  
Author(s):  
Clara Ameixa ◽  
Jon S. Friedland
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Tyrosine Kinases ◽  
Nuclear Translocation ◽  
Interleukin 8 ◽  
Protein Tyrosine Kinases ◽  
Human Monocytes ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Posttranscriptional Processing

ABSTRACT Mycobacterium tuberculosis upregulates NF-κB binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes. Inhibition of tyrosine protein kinases but not of ERK1/2 or p38 mitogen-activated protein kinases downregulates tuberculosis-induced IL-8 secretion. The inhibitor genistein decreased NF-κB nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.

Sign in / Sign up

Export Citation Format

Share Document