Mitogen-activated protein kinases mediate the production of B-cell lymphoma 2 protein by Mycobacterium tuberculosis in Monocytes

2011 ◽  
Vol 76 (8) ◽  
pp. 938-950 ◽  
Author(s):  
P. L. Natarajan ◽  
Sujatha Narayanan
Keyword(s):  
Mycobacterium Tuberculosis ◽  
B Cell ◽  
Protein Kinases ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals Phosphorylation of Mitogen-Activated Protein Kinases Contributes to Interferon γ Production in Response to Mycobacterium tuberculosis

2012 ◽  
Vol 207 (2) ◽  
pp. 340-350 ◽  
Author(s):  
Virginia Pasquinelli ◽  
Ana I. Rovetta ◽  
Ivana B. Alvarez ◽  
Javier O. Jurado ◽  
Rosa M. Musella ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Interferon Γ ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals Interleukin-8 Secretion from Mycobacterium tuberculosis-Infected Monocytes Is Regulated by Protein Tyrosine Kinases but Not by ERK1/2 or p38 Mitogen-Activated Protein Kinases

2002 ◽  
Vol 70 (8) ◽  
pp. 4743-4746 ◽  
Author(s):  
Clara Ameixa ◽  
Jon S. Friedland
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Protein Kinases ◽  
Tyrosine Kinases ◽  
Nuclear Translocation ◽  
Interleukin 8 ◽  
Protein Tyrosine Kinases ◽  
Human Monocytes ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Posttranscriptional Processing

ABSTRACT Mycobacterium tuberculosis upregulates NF-κB binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes. Inhibition of tyrosine protein kinases but not of ERK1/2 or p38 mitogen-activated protein kinases downregulates tuberculosis-induced IL-8 secretion. The inhibitor genistein decreased NF-κB nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.

scholarly journals Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

FEBS Letters ◽  
2001 ◽  
Vol 490 (1-2) ◽  
pp. 97-101 ◽  
Author(s):  
Mami Ogimoto ◽  
Yutaka Arimura ◽  
Tatsuo Katagiri ◽  
Katsuyuki Mitomo ◽  
James R. Woodgett ◽  
...  
Keyword(s):  
B Cell ◽  
Protein Kinases ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Di Wang ◽  
Jiahui Lu ◽  
Yan Liu ◽  
Qingfan Meng ◽  
Jing Xie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Kinase ◽  
Cell Viability ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Mitogen Activated Protein Kinase ◽  
Mice Model ◽  
Tumor Cell Death ◽  
Mitogen Activated Protein

Liquiritigenin (LQ), separated fromGlycyrrhiza radix, possesses anti-inflammatory, antihyperlipidemic, and antiallergic effects. Our present study aims to investigate the antihepatocellular carcinoma effects of LQ both in cell and animal models. LQ strikingly reduced cell viability, enhanced apoptotic rate, induced lactate dehydrogenase over-release, and increased intracellular reactive oxygen species (ROS) level and caspase 3 activity in both PLC/PRL/5 and HepG2 cells. The expression of cleaved PARP, the hall-marker of apoptosis, was enhanced by LQ. LQ treatment resulted in a reduction of the expressions of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL), and an increase of the phosphorylation of c-Jun N-terminal kinases (JNK) and P38. LQ-mediated cell viability reduction, mitochondrial dysfunction, apoptosis related protein abnormal expressions, and JNK and P38 activation were partially abolished by N-Acetyl-L-cysteine (a ROS inhibitor) pretreatment. Moreover, LQ suppressed the activation of extracellular signaling-regulated kinase (ERKs) and reduced the translocation of phosphor-ERKs from cytoplasm to nucleus. This antitumor activity was further confirmed in PLC/PRL/5-xenografted mice model. All these data indicate that the antihepatocellular carcinoma effects of LQ are related to its modulation of the activations of mitogen-activated protein kinase (MAPKs). The study provides experimental evidence supporting LQ as a potential therapeutic agent for hepatocellular carcinoma treatment.

scholarly journals INCREASED RISK OF LYMPHOMA IN MEN INFECTED WITH TUBERCULOSIS

2021 ◽  
Vol 13 (1) ◽  
pp. e2021053
Author(s):  
Guangliang Chen
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
B Cell ◽  
Hodgkin’S Lymphoma ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Male Gender ◽  
Hodgkin's Lymphoma ◽  
Benign Tumors ◽  
Control Analysis

Purpose: To identify factors associated with lymphoma in patients with anterior Mycobacterium tuberculosis (TB). Methods: A retrospective case-control analysis was performed in a highly tuberculosis-endemic area. TB-infected patients were retrospectively identified when a history of TB exists before the diagnosis of lymphoma. Inpatients with lymphoma (n=1,057) and benign tumors (n=12,916) were consecutively enrolled at Xinjiang Medical University Cancer Hospital between January 2016 and December 2019. Results: The proportion of TB in patients with lymphoma (n=148, 14.0%) was significantly higher than that in the control (benign tumor) group (n=175, 1.4%) (p<0.0001). The frequency of TB infection in patients with Hodgkin’s lymphoma, B-cell non-Hodgkin’s lymphoma (NHL), and T/NK-cell NHL is 13.6%, 14.6%, and 11.9%, respectively. Compared to other subtypes of B-cell NHL, a relatively high proportion of tuberculosis was found in patients with chronic lymphocytic leukemia /small lymphocytic lymphoma, marginal zone B-cell lymphoma, diffuse large B-cell lymphoma, corresponding to 20.6%, 18.6% and 15.3%, respectively. For T-cell NHL, the proportion of TB infection in patients with peripheral T-cell lymphoma and anaplastic lymphoma kinase-positive T-cell NHL was 26.1% and 20%, respectively. Multivariate analysis revealed male gender as an adverse risk factor was associated with lymphoma after tubercular infection. In addition, male gender and old age (>60 years) was associated with the B-cell NHL. Conclusion: A high proportion of Mycobacterium tuberculosis infection was found in patients with lymphoma. In TB-infected patients, older age and male gender are associated with susceptibility to lymphoma, suggesting the awareness of a screening program might be useful for early detection of lymphoma.

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