Activities of Ceftobiprole and Other β-Lactams against Streptococcus pneumoniae Clinical Isolates from the United States with Defined Substitutions in Penicillin-Binding Proteins PBP 1a, PBP 2b, and PBP 2x
2006 ◽
Vol 50
(7)
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pp. 2530-2532
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Keyword(s):
ABSTRACT The activities of ceftobiprole and other β-lactams were examined with 30 Streptococcus pneumoniae isolates containing multiple pbp1a, pbp2b, and pbp2x mutations. The highest ceftobiprole MIC was 1 μg/ml, while the comparator MICs were 16 to 64 μg/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 μg/ml (ceftobiprole) and 4 μg/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.
2007 ◽
Vol 51
(9)
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pp. 3404-3406
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2002 ◽
Vol 46
(12)
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pp. 3744-3749
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2002 ◽
Vol 43
(3)
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pp. 207-217
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Keyword(s):
2008 ◽
Vol 53
(3)
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pp. 1238-1241
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2010 ◽
Vol 54
(11)
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pp. 4945-4947
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1989 ◽
Vol 86
(22)
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pp. 8842-8846
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1980 ◽
Vol 17
(3)
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pp. 364-371
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Keyword(s):
1986 ◽
Vol 30
(6)
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pp. 906-912
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