scholarly journals Pharmacokinetics of Caspofungin in Critically Ill Patients on Continuous Renal Replacement Therapy

2013 ◽  
Vol 57 (8) ◽  
pp. 4053-4057 ◽  
Author(s):  
Stefan Weiler ◽  
Christoph Seger ◽  
Hartwig Pfisterer ◽  
Eva Stienecke ◽  
Florian Stippler ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Healthy Volunteers ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Control Group ◽  
Continuous Venovenous Hemofiltration ◽  
Standard Dosage ◽  
Continuous Venovenous Hemodialysis

ABSTRACTCaspofungin pharmacokinetics was assessed in 27 critically ill patients, including 7 on continuous venovenous hemofiltration (CVVH), 8 on continuous venovenous hemodialysis (CVVHD), and 13 not requiring continuous renal replacement therapy (CRRT). Caspofungin exposure during CRRT was very similar to that of the control group and comparable to that in healthy volunteers. Caspofungin clearance by CRRT was very low. Therefore, the standard dosage of caspofungin is probably adequate for critically ill patients undergoing CVVH or CVVHD.

scholarly journals Pharmacokinetics of Levofloxacin and Ciprofloxacin during Continuous Renal Replacement Therapy in Critically Ill Patients

2001 ◽  
Vol 45 (10) ◽  
pp. 2949-2954 ◽  
Author(s):  
Rebecca S. Malone ◽  
Douglas N. Fish ◽  
Edward Abraham ◽  
Isaac Teitelbaum
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Effective Drug ◽  
Continuous Venovenous Hemofiltration ◽  
Drug Concentrations

ABSTRACT The pharmacokinetics of intravenously administered levofloxacin and ciprofloxacin were studied in intensive care unit patients during continuous venovenous hemofiltration (CVVH; four patients received levofloxacin, and five received ciprofloxacin) or hemodiafiltration (CVVHDF; six patients received levofloxacin, and five received ciprofloxacin). Levofloxacin clearance was substantially increased during both CVVH and CVVHDF, while ciprofloxacin clearance was affected less. The results of this study suggest that doses of levofloxacin of 250 mg/day and ciprofloxacin of 400 mg/day are sufficient to maintain effective drug concentrations in the plasma of patients undergoing CVVH or CVVHDF.

scholarly journals Vancomycin therapy in critically ill patients on continuous renal replacement therapy; are we doing enough?

2015 ◽  
Vol 23 (3) ◽  
pp. 327-329 ◽  
Author(s):  
Ali S. Omrani ◽  
Alaa Mously ◽  
Marylie P. Cabaluna ◽  
John Kawas ◽  
Mohammed M. Albarrak ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Vancomycin Therapy
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