scholarly journals In Vitro Activity of Ceftaroline against Community-Associated Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Daptomycin-Nonsusceptible Staphylococcus aureus Isolates

2010 ◽  
Vol 54 (7) ◽  
pp. 3027-3030 ◽  
Author(s):  
Louis Saravolatz ◽  
Joan Pawlak ◽  
Leonard Johnson
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Option ◽  
Bactericidal Activity ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Methicillin Resistant ◽  
Vancomycin Resistant

ABSTRACT This study assessed the in vitro activities of ceftaroline and five comparator agents against a collection of Staphylococcus aureus isolates. Ceftaroline demonstrated potent activity against community-associated methicillin-resistant S. aureus (CA-MRSA) isolates and showed bactericidal activity against vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA), heteroresistant VISA (hVISA), and daptomycin-nonsusceptible S. aureus (DNSSA) isolates. Ceftaroline may represent a bactericidal treatment option for infections caused by these pathogens.

scholarly journals Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates

2009 ◽  
Vol 53 (5) ◽  
pp. 2171-2175 ◽  
Author(s):  
Helio S. Sader ◽  
Thomas R. Fritsche ◽  
Ronald N. Jones
Keyword(s):  
United States ◽  
Staphylococcus Aureus ◽  
Enterococcus Faecalis ◽  
Bactericidal Activity ◽  
The United States ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Methicillin Resistant

ABSTRACT The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. In addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.

scholarly journals In vitro activity of LY333328, an investigational glycopeptide antibiotic, against enterococci and staphylococci.

1996 ◽  
Vol 40 (10) ◽  
pp. 2416-2419 ◽  
Author(s):  
R S Schwalbe ◽  
A C McIntosh ◽  
S Qaiyumi ◽  
J A Johnson ◽  
R J Johnson ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Glycopeptide Antibiotic ◽  
Methicillin Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

The in vitro activities of LY333328 were compared with those of vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MICs and MBCs were determined by a microtiter dilution protocol. LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal. Its potency was comparable or superior to those of other antibiotics tested against methicillin-resistant staphylococci.

scholarly journals In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus

2011 ◽  
Vol 64 (8) ◽  
pp. 559-562 ◽  
Author(s):  
Chunguang Sun ◽  
Matthew E Falagas ◽  
Rui Wang ◽  
Drosos E Karageorgopoulos ◽  
Xuhong Yu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Methicillin Resistant
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