In Vitro and Intracellular Activity of Imipenem Combined with Tedizolid, Rifabutin, and Avibactam against Mycobacterium abscessus
Keyword(s):
ABSTRACT Mycobacterium abscessus infections are difficult to treat because of their resistance to many antibiotics. In vitro, tedizolid combined with imipenem displayed a moderate synergistic effect (fractional inhibitory concentration index, 0.41) but no bactericidal activity. Intracellularly, tedizolid 2 μg/ml (half of the MIC), corresponding to the peak serum concentration, increased the efficacy of imipenem at 8 and 32 μg/ml. Addition of avibactam and rifabutin, alone or in combination, improved the activity of the imipenem-tedizolid combination.
2005 ◽
Vol 49
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pp. 3544-3545
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2000 ◽
Vol 44
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pp. 2179-2181
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2012 ◽
Vol 56
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pp. 3785-3796
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2011 ◽
Vol 55
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pp. 4485-4487
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