Removal of Dolutegravir by Hemodialysis in HIV-Infected Patients with End-Stage Renal Disease
2016 ◽
Vol 60
(4)
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pp. 2564-2566
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Keyword(s):
ABSTRACTData on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting. (This study is registered at ClinicalTrials.gov under registration number NCT02487706.)
2002 ◽
Vol 13
(5)
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pp. 1331-1337
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Keyword(s):
1993 ◽
Vol 91
(2)
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pp. 397-401
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Keyword(s):
Minimal Removal of Raltegravir by Hemodialysis in HIV-Infected Patients with End-Stage Renal Disease
2010 ◽
Vol 54
(7)
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pp. 3047-3048
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Keyword(s):
Keyword(s):
1999 ◽
Vol 19
(5)
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pp. 612-619
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Keyword(s):
2017 ◽
Vol 10
◽
pp. 117863291771302
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