Efavirenz Pharmacokinetics in Cerebrospinal Fluid and Plasma over a 24-Hour Dosing Interval
2012 ◽
Vol 56
(9)
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pp. 4583-4585
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Keyword(s):
ABSTRACTWe determined the pharmacokinetics of efavirenz in plasma and cerebrospinal fluid (CSF) over a 24-h dosing interval in a patient who had undergone a lumbar drain because of cryptococcal meningitis. Drug concentrations were determined by high-performance liquid chromatography-tandem mass spectrometry in paired CSF (n= 24) and plasma (n= 25) samples. The median plasma efavirenz concentration was 3,718 ng/ml (range, 2,439 to 4,952), and the median CSF concentration was 16.3 ng/ml (range, 7.3 to 22.3). The CSF/plasma area-under-the-curve ratio was 0.0044 corresponding to a CSF penetration of 0.44% of plasma.
2018 ◽
Vol 1091
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pp. 53-66
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2007 ◽
Vol 43
(5)
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pp. 1728-1736
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2013 ◽
Vol 83
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pp. 1-9
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2016 ◽
Vol 1437
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pp. 145-157
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2017 ◽
Vol 274
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pp. 70-74
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2018 ◽
Vol 62
(4)
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pp. e02448-17
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2006 ◽
2019 ◽