Inhibition of Human Immunodeficiency Virus Type 1 Infection in SCID-hu Thy/Liv Mice by the G-Quartet-Forming Oligonucleotide, ISIS 5320
1998 ◽
Vol 42
(8)
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pp. 2113-2115
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Keyword(s):
ABSTRACT Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate.
2008 ◽
Vol 52
(2)
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pp. 518-525
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2000 ◽
Vol 74
(15)
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pp. 7039-7047
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2003 ◽
Vol 84
(10)
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pp. 2715-2722
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Keyword(s):
2003 ◽
Vol 77
(5)
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pp. 3119-3130
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2001 ◽
Vol 75
(8)
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pp. 3916-3924
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