Efficacies of Quinupristin-Dalfopristin Combined with Vancomycin In Vitro and in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus in Relation to Cross-Resistance to Macrolides, Lincosamides, and Streptogramin B- Type Antibiotics
2002 ◽
Vol 46
(9)
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pp. 3061-3064
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Keyword(s):
ABSTRACT A beneficial effect of the combination of quinupristin-dalfopristin and vancomycin was observed against two methicillin-resistant strains of Staphylococcus aureus harboring or not harboring the ermC gene, which codes for constitutive macrolide, lincosamide, and streptogramin B resistance. The beneficial effect was observed in time-kill studies, in which the drugs were used at inhibitory concentrations, and in a rabbit model of endocarditis, in which the combination was highly bactericidal and more active than monotherapies.
2005 ◽
Vol 49
(8)
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pp. 3163-3165
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2009 ◽
Vol 53
(10)
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pp. 4172-4177
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2004 ◽
Vol 48
(10)
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pp. 4016-4019
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2016 ◽
Vol 60
(7)
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pp. 4342-4345
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2009 ◽
Vol 53
(10)
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pp. 4495-4497
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2012 ◽
Vol 56
(5)
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pp. 2753-2755
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2012 ◽
Vol 56
(11)
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pp. 5528-5533
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1996 ◽
Vol 40
(10)
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pp. 2428-2430
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