scholarly journals Characterization of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis in Brazil

2005 ◽  
Vol 49 (1) ◽  
pp. 444-446 ◽  
Author(s):  
Vívian de F. Sumnienski Rodrigues ◽  
Maria Alice Telles ◽  
Marta Osório Ribeiro ◽  
Patrícia Izquierdo Cafrune ◽  
Maria Lucia Rosa Rossetti ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Nucleotide Sequence ◽  
Clinical Isolates

ABSTRACT In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

scholarly journals Characterization of mutations in streptomycin-resistant Mycobacterium tuberculosis clinical isolates in the area of Barcelona

2010 ◽  
Vol 65 (11) ◽  
pp. 2341-2346 ◽  
Author(s):  
G. Tudo ◽  
E. Rey ◽  
S. Borrell ◽  
F. Alcaide ◽  
G. Codina ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Isolates

scholarly journals Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China

2008 ◽  
Vol 46 (12) ◽  
pp. 4075-4077 ◽  
Author(s):  
Z. Sun ◽  
Y. Chao ◽  
X. Zhang ◽  
J. Zhang ◽  
Y. Li ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Extensively Drug Resistant

Genetic characterization of Mycobacterium tuberculosis clinical isolates with deletions in the plcA–plcB–plcC locus

Tuberculosis ◽  
2007 ◽  
Vol 87 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Lucio Vera-Cabrera ◽  
Carmen A. Molina-Torres ◽  
Marco A. Hernández-Vera ◽  
Hugo B. Barrios-García ◽  
Kym Blackwood ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Genetic Characterization ◽  
Clinical Isolates

scholarly journals Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.

1997 ◽  
Vol 41 (9) ◽  
pp. 2057-2058 ◽  
Author(s):  
C L Kelley ◽  
D A Rouse ◽  
S L Morris
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Nucleotide Sequence ◽  
Gene Mutations ◽  
Clinical Isolates ◽  
Sequence Analyses ◽  
Promoter Mutations

The ahpC genes of 57 clinical isolates and one in vitro mutant of Mycobacterium tuberculosis were evaluated by nucleotide sequence analyses. Although compensatory ahpC promoter mutations were identified in 8 catalase-negative, katG-defective strains, the ahpC genes of 25 catalase-positive, isoniazid-resistant isolates and 25 drug-sensitive strains were not altered.

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