scholarly journals Parameters of disease progression in long-term experimental feline retrovirus (feline immunodeficiency virus and feline leukemia virus) infections: hematology, clinical chemistry, and lymphocyte subsets.

1997 ◽  
Vol 4 (1) ◽  
pp. 33-42 ◽  
Author(s):  
R Hofmann-Lehmann ◽  
E Holznagel ◽  
P Ossent ◽  
H Lutz
Keyword(s):  
Disease Progression ◽  
Feline Immunodeficiency Virus ◽  
Lymphocyte Subsets ◽  
Clinical Chemistry ◽  
Leukemia Virus ◽  
Feline Leukemia Virus ◽  
Virus Infections ◽  
Immunodeficiency Virus

scholarly journals Histologic Classification and Immunophenotype of Lymphosarcomas in Cats with Naturally and Experimentally Acquired Feline Immunodeficiency Virus Infections

1996 ◽  
Vol 33 (3) ◽  
pp. 264-272 ◽  
Author(s):  
J. J. Callanan ◽  
B. A. Jones ◽  
J. Irvine ◽  
B. J. Willett ◽  
I. A. P. McCandlish ◽  
...  
Keyword(s):  
B Cell ◽  
Feline Immunodeficiency Virus ◽  
Cell Activation ◽  
Polyclonal Antibodies ◽  
Leukemia Virus ◽  
Feline Leukemia Virus ◽  
B Cell Activation ◽  
Virus Infections ◽  
Histologic Classification ◽  
Immunodeficiency Virus

Lymphosarcoma (malignant lymphoma) is the commonest hematopoietic tumor in the cat. Many cases are associated with feline leukemia virus (FeLV) infection, but epidemiologic and experimental data suggest that feline immunodeficiency virus (FIV) may also have a role in lymphomagenesis. In this paper, we describe the clinical presentation, histologic classification, and immunophenotype of lymphosarcoma in eight domestic cats with natural or experimental FIV infections. The tumors were often of unusual distribution, with the majority of cases conforming to the least common anatomic classification of “miscellaneous.” Histopathologic and immunophenotypic analysis using a panel of anti-cat and cross-reactive anti-human monoclonal and polyclonal antibodies identified seven of these tumors as high-grade B cell lymphomas of the centroblastic or immunoblastic subtypes. The remaining case was a T-cell tumor associated with a concurrent FeLV infection. Our findings, together with the results of an analysis of FIV proviral DNA in these tumors, indicate that the B-cell lymphosarcomas were comparable to those observed in human and simian immunodeficiency virus infections and that the role of FIV in lymphomagenesis is indirect and related to the potential for malignant transformation during polyclonal B cell activation.

scholarly journals Viral Prevalence in Wild Serval Population is Driven by Season and Sex

EcoHealth ◽  
2021 ◽  
Author(s):  
Daan J. E. Loock ◽  
Emilio Rendón-Franco ◽  
Samual T. Williams ◽  
Johan van Niekerk ◽  
Lourens H. Swanepoel
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Leukemia Virus ◽  
Feline Leukemia Virus ◽  
Key Factors ◽  
Feline Panleukopenia Virus ◽  
Factors Influencing ◽  
Immunodeficiency Virus ◽  
Feline Coronavirus ◽  
Long Term Studies

AbstractOne of the key factors influencing the population dynamics of threatened species such as felids is disease, but long-term studies of the factors influencing seroprevalence of wild felids are extremely rare, hindering conservation efforts. We set out to determine seroprevalence of six viral diseases (feline panleukopenia virus, feline leukemia virus, feline coronavirus, feline calicivirus, feline herpes virus, and feline immunodeficiency virus) among a population of serval (Leptailurus serval) with an extremely high density in South Africa. We captured 55 individuals over four years and screened blood samples for antibodies to each virus. We found that seroprevalence were high (ranging from 30.0% positive for a single virus to 1.8% positive for up to five viruses) and that seroprevalence was influenced by season and sex, but not body condition. We suggest further monitoring of this population and recommend that long-term studies are conducted for serval and other felids to determine whether these trends are representative on a broader scale.

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