scholarly journals Comparison of Specific Serological Assays for Diagnosing Human Herpesvirus 6 Infection after Liver Transplantation

2001 ◽  
Vol 8 (1) ◽  
pp. 170-173 ◽  
Author(s):  
Tetsushi Yoshikawa ◽  
Jodi B. Black ◽  
Masaru Ihira ◽  
Kyoko Suzuki ◽  
Sadao Suga ◽  
...  
Keyword(s):  
Antibody Titer ◽  
Human Herpesvirus ◽  
Neutralizing Antibody ◽  
Cross Reactivity ◽  
Significant Rise ◽  
Immunoglobulin M ◽  
Antibody Responses ◽  
Human Herpesvirus 6 ◽  
Igm Antibody ◽  
Herpesvirus 6

ABSTRACT Cross-reactivity between human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) antibodies and the reliability of specific serological assays were analyzed for 12 patients with concurrent HHV-6 and HHV-7 antibody responses after transplantation with a liver from a living relative by using an immunofluorescence assay (IFA). A neutralizing antibody titer assay (NT) and an immunoblot assay (IB) designed to detect immunoglobulin M (IgM) antibody to the HHV-6 immunodominant 101-kDa protein were compared in the diagnosis of an active HHV-6 infection. A total of 9 of 12 patients demonstrated concurrent HHV-6 and HHV-7 antibody responses, including increased IgG titers and/or the presence of IgM by IFA, and were thus analyzed for cross-reactive antibody to heterologous virus. The average percentages of residual antibody to HHV-6 and HHV-7 after absorption with HHV-6 antigen were 32.6% (range, 6 to 50%) and 55.6% (range, 35 to 100%), respectively. All 12 patients were subsequently analyzed for HHV-6 antibody by using IB and NT. IB detected IgM antibody to the 101-kDa protein in 75% (9 of 12) of the recipients. A significant rise in the NT antibody titer was detected in the same nine samples. However, HHV-6 DNA was detected by PCR in only five of nine plasma samples collected from recipients with a specific serologic response against HHV-6.

scholarly journals IgM Neutralizing Antibody Responses to Human Herpesvirus-6 in Patients with Exanthem Subitum or Organ Transplantation

1992 ◽  
Vol 36 (5) ◽  
pp. 495-506 ◽  
Author(s):  
Sadao Suga ◽  
Tetsushi Yoshikawa ◽  
Yoshizo Asano ◽  
Toshihiko Nakashima ◽  
Takehiko Yazaki ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Human Herpesvirus ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Herpesvirus 6

scholarly journals Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6)

Viruses ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 317 ◽  
Author(s):  
Uwe Fiebig ◽  
Angela Holzer ◽  
Daniel Ivanusic ◽  
Elena Plotzki ◽  
Hartmut Hengel ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Cross Reactivity ◽  
Human Herpesvirus 6 ◽  
Porcine Cytomegalovirus ◽  
Herpesvirus 6

Antibody Responses to Epstein-Barr Virus, Human Herpesvirus 6 and Human Herpesvirus 7 in Patients with Chronic Fatigue Syndrome

Intervirology ◽  
1995 ◽  
Vol 38 (5) ◽  
pp. 269-273 ◽  
Author(s):  
Takeshi Sairenji ◽  
Koichi Yamanishi ◽  
Yoichi Tachibana ◽  
Giuseppe Bertoni ◽  
Takeshi Kurata
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Chronic Fatigue ◽  
Antibody Responses ◽  
Human Herpesvirus 6 ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Herpesvirus 6 ◽  
Epstein Barr

scholarly journals Human herpesvirus 6 and multiple sclerosis: A study of t cell cross-reactivity to viral and myelin basic protein antigens

2002 ◽  
Vol 68 (2) ◽  
pp. 268-272 ◽  
Author(s):  
Mara Cirone ◽  
Laura Cuomo ◽  
Claudia Zompetta ◽  
Stefano Ruggieri ◽  
Luigi Frati ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Human Herpesvirus ◽  
Cross Reactivity ◽  
Human Herpesvirus 6 ◽  
Protein Antigens ◽  
Herpesvirus 6

scholarly journals Human herpesvirus-6 viral load and antibody titer in serum samples of patients with multiple sclerosis

2011 ◽  
Vol 44 (4) ◽  
pp. 247-251 ◽  
Author(s):  
Abbas Behzad-Behbahani ◽  
Mohammad Hadi Mikaeili ◽  
Mona Entezam ◽  
Anahita Mojiri ◽  
Gholamreza Yousefi Pour ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Viral Load ◽  
Antibody Titer ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Serum Samples ◽  
Herpesvirus 6

Human Herpesvirus 6 Infection in Hemodialysis and Peritoneal Dialysis Patients

2011 ◽  
Vol 31 (3) ◽  
pp. 320-324 ◽  
Author(s):  
Mustafa Altay ◽  
Hatice Akay ◽  
Selman Ünverdi ◽  
Filiz Altay ◽  
Mevlüt Çeri ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Organ Transplantation ◽  
Hepatitis B Surface Antigen ◽  
Human Herpesvirus ◽  
Immunoglobulin M ◽  
Human Herpesvirus 6 ◽  
Igg Antibody ◽  
Control Subjects ◽  
History Of ◽  
Herpesvirus 6

BackgroundHuman herpesvirus 6 (HHV-6) infection occurs worldwide and can be reactivated from latency during periods of immunosuppression, especially after organ transplantation. No previous study has evaluated the influence of dialysis type on HHV-6 infection. The aim of the present study was to determine the prevalence of HHV-6 antibodies in hemodialysis (HD) and peritoneal dialysis (PD) patients.MethodsW e studied 36 PD patients, 35 HD patients, and 20 healthy subjects, all with no history of organ transplantation. After systematic inquiries and a physical examination, blood was drawn for determination of biochemical parameters, cytomegalovirus immunoglobulin M (IgM) and immunoglobulin G (IgG), hepatitis B surface antigen, and the hepatitis C and human immunodeficiency virus antibodies. Titers of HHV-6 IgM and IgG antibodies were determined by ELISA.ResultsTiters for HHV-6 IgM antibody were positive in 9 HD patients (25.7%), 8 PD patients (22.2%), and 2 control subjects (10.0%, p > 0.05). More HD patients (20.0%) than PD patients (5.6%, p = 0.07) or control subjects (0.0%, p =0.03) were positive for HHV-6 IgG antibody. In HD patients, HHV-6 IgG seropositivity and duration of dialysis were positively correlated (R = 0.33, p = 0.05).ConclusionsInfection with HHV-6 is not rare in PD and HD patients. In addition, HHV-6 IgG seropositivity was significantly higher in H D patients than in control subjects and approached significance when compared with seropositivity in PD patients. Moreover, in HD patients, HHV-6 IgG seropositivity correlated with duration on HD. These preliminary findings provide insight into the pre-transplantation period for patients and may aid our understanding of how to best protect patients against HHV-6 after transplantation.

ANTIBODY RESPONSES TO HUMAN HERPESVIRUS 6 AND OTHER HERPESVIRUSES

The Lancet ◽  
1988 ◽  
Vol 332 (8625) ◽  
pp. 1425-1426 ◽  
Author(s):  
DavidJ. Morris ◽  
Edward Littler ◽  
Debbie Jordan ◽  
JohnR. Arrand ◽  
Martin Andre ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Antibody Responses ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Clinical Features of Infants With Primary Human Herpesvirus 6 Infection (Exanthem Subitum, Roseola Infantum)

PEDIATRICS ◽  
1994 ◽  
Vol 93 (1) ◽  
pp. 104-108
Author(s):  
Yoshizo Asano ◽  
Tetsushi Yoshikawa ◽  
Sadao Suga ◽  
Ikuko Kobayashi ◽  
Toshihiko Nakashima ◽  
...  
Keyword(s):  
Clinical Features ◽  
Large Scale ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Human Herpesvirus ◽  
Neutralizing Antibody ◽  
Signs And Symptoms ◽  
Human Herpesvirus 6 ◽  
Exanthem Subitum ◽  
Herpesvirus 6

Objective. To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study. Subjects and methods. Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both. Results. The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4°C) and lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68%, edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging of the anterior fontanelle and 8% had convulsions. Conclusions. Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.

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