scholarly journals Expression of a Novel Protein by Regenerating Hepatocytes and Peripheral Blood Lymphocytes

2001 ◽  
Vol 8 (6) ◽  
pp. 1292-1294
Author(s):  
Antonio Chedid ◽  
Ching C. Sung ◽  
Maria R. Lepe ◽  
Syed A. Ahmed ◽  
Syeda A. Iftikhar ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Peripheral Blood ◽  
Alcoholic Cirrhosis ◽  
Peripheral Blood Lymphocytes ◽  
Immunosuppressive Activity ◽  
Blood Lymphocytes ◽  
Novel Protein

ABSTRACT Regeneration and tolerance factor (RTF) is a protein with immunosuppressive activity and is normally present in the thymus and placenta. RTF was measured in the livers of patients with regenerating nodules due to alcoholic cirrhosis and hepatitis C. RTF was expressed in the regenerating nodules of 26 patients with alcoholic cirrhosis. All patients with chronic hepatitis C without cirrhosis failed to express RTF. Flow cytometry revealed upregulation of RTF on the lymphocytes from alcoholic cirrhosis and downregulation in hepatitis C disease.

Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection

Hepatology ◽  
1995 ◽  
Vol 22 (4) ◽  
pp. 1057-1064 ◽  
Author(s):  
Kazuo Iwata ◽  
Takaji Wakita ◽  
Akihiko Okumura ◽  
Kentaro Yoshioka ◽  
Masahiro Takayanagi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Gamma ◽  
Peripheral Blood ◽  
Core Protein ◽  
Peripheral Blood Lymphocytes ◽  
Hepatitis C Infection ◽  
Virus Core
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