scholarly journals Exercise and Sleep Deprivation Do Not Change Cytokine Expression Levels in Patients with Chronic Fatigue Syndrome

2013 ◽  
Vol 20 (11) ◽  
pp. 1736-1742 ◽  
Author(s):  
Toru Nakamura ◽  
Stephan Schwander ◽  
Robert Donnelly ◽  
Dane B. Cook ◽  
Felix Ortega ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sleep Deprivation ◽  
Proinflammatory Cytokines ◽  
Physical Exertion ◽  
Chronic Fatigue ◽  
Immune Dysregulation ◽  
Peripheral Blood Lymphocytes ◽  
Protein Levels ◽  
Fatigue Syndrome ◽  
And Function

ABSTRACTA major hypothesis regarding the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to be reflected in upregulated proinflammatory cytokines leading to the symptoms that are characteristic of this illness. Because the symptoms worsen with physical exertion or sleep loss, we hypothesized that we could use these stressors to magnify the underlying potential pathogenic abnormalities in the cytokine systems of people with CFS. We conducted repeat blood sampling for cytokine levels from healthy subjects and CFS patients during both postexercise and total sleep deprivation nights and assayed for protein levels in the blood samples, mRNA activity in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found that these environmental manipulations did not produce clinically significant upregulation of proinflammatory cytokines. These data do not support an important role of immune dysregulation in the genesis of stress-induced worsening of CFS.

scholarly journals Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

2010 ◽  
Vol 17 (4) ◽  
pp. 582-587 ◽  
Author(s):  
Toru Nakamura ◽  
Stephan K. Schwander ◽  
Robert Donnelly ◽  
Felix Ortega ◽  
Fumiharu Togo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Interleukin 10 ◽  
Peripheral Blood Lymphocytes ◽  
Fatigue Syndrome ◽  
The Common ◽  
Cytokine Dysregulation ◽  
And Function ◽  
Anti Inflammatory Cytokine ◽  
Better Than

ABSTRACT The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.

scholarly journals The Disrupted and Realigned Self: Exploring the Narratives of New Zealanders with  Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2021 ◽  
Author(s):  
◽  
Lara Joyce Milka Bell
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Participant Observation ◽  
Physical Exertion ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Community Interactions ◽  
Self Identity ◽  
Authentic Self ◽  
Fatigue Syndrome ◽  
The Individual

<p>Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) causes pronounced, debilitating fatigue that is not alleviated by rest, along with muscle and joint weakness, pain, cognitive difficulties and can be worsened through mental and physical exertion. However, it is also without an aetiology, and there is little consensus amongst both medical and patient spheres as to what CFS/ME actually is. In this thesis I draw on interviews with people with CFS/ME and participant observation in a patient-led support group in order to explore the way in which CFS/ME shaped participants’ identities and narratives of the self. I argue that participants moved through two stages that I call ‘The Disrupted Self’ and ‘The Realigned Self’. Falling ill with CFS/ME rapidly disrupted participants’ understandings of the bodies, their position within their family and the community, interactions with doctors, and all the usual markers on which they had previously formed their self-identities. In this state, I argue that participants and those with whom they engaged viewed both CFS/ME and my participants as liminal, ‘betwixt and between’ (Turner 1969) social roles and contemporary New Zealand ideals of illness, the individual, and the ‘sick person’. As the initial disruption and confusion of falling ill subsided, however, my participants worked to develop a new secure self-identity, the ‘Realigned Self’. They move into a normalised long-term liminal state by prioritising their health, adjusting their expectations of their body, developing their own conception of the aetiology of CFS/ME and forming a positive narrative of their new lives. This identity work utilised wider cultural ideals about the active, responsibilised and authentic self; common to late modern contemporary life (Beck and Beck-Gernsheim 2001, Desjarlais 1994, Giddens 1991, Rose 1996). Yet this realignment was often not reflected in the views of my participants’ friends, families and doctors. This illustrates the diverse perspectives and different degrees of liminality that exist within experiences and narratives of CFS/ME and contested illnesses.</p>

scholarly journals Corrigendum: Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Jakob Theorell ◽  
Indre Bileviciute-Ljungar ◽  
Bianca Tesi ◽  
Heinrich Schlums ◽  
Mette Sophie Johnsgaard ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Cytotoxic Lymphocyte ◽  
Fatigue Syndrome ◽  
Lymphocyte Phenotype ◽  
And Function

Lymphocyte phenotype and function in the chronic fatigue syndrome

1993 ◽  
Vol 13 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Stephen E. Straus ◽  
Scott Fritz ◽  
Janet K. Dale ◽  
Barbara Gould ◽  
Warren Strober
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Lymphocyte Phenotype ◽  
And Function

scholarly journals Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome

2013 ◽  
Vol 11 (1) ◽  
pp. 68 ◽  
Author(s):  
Marta Curriu ◽  
Jorge Carrillo ◽  
Marta Massanella ◽  
Josepa Rigau ◽  
José Alegre ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Cell Phenotype ◽  
Fatigue Syndrome ◽  
And Function

scholarly journals Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

2017 ◽  
Vol 8 ◽  
Author(s):  
Jakob Theorell ◽  
Indre Bileviciute-Ljungar ◽  
Bianca Tesi ◽  
Heinrich Schlums ◽  
Mette Sophie Johnsgaard ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Cytotoxic Lymphocyte ◽  
Fatigue Syndrome ◽  
Lymphocyte Phenotype ◽  
And Function

scholarly journals Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 406
Author(s):  
Per Ole Iversen ◽  
Thomas Gero von Lueder ◽  
Kristin Reimers Kardel ◽  
Katarina Lien
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Lactate Production ◽  
Study Groups ◽  
Chronic Fatigue ◽  
Tissue Doppler ◽  
Myalgic Encephalomyelitis ◽  
Exercise Intolerance ◽  
Healthy Controls ◽  
Fatigue Syndrome ◽  
And Function

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition associated with several negative health outcomes. A hallmark of ME/CFS is decreased exercise capacity and often profound exercise intolerance. The causes of ME/CSF and its related symptoms are unknown, but there are indications of a dysregulated metabolism with impaired glycolytic vs oxidative energy balance. In line with this, we recently demonstrated abnormal lactate accumulation among ME/CFS patients compared with healthy controls after exercise testing. Here we examined if cardiac dimensions and function were altered in ME/CFS, as this could lead to increased lactate production. Methods: We studied 16 female ME/CFS patients and 10 healthy controls with supine transthoracic echocardiography, and we assessed cardiac dimensions and function by conventional echocardiographic and Doppler analysis as well as novel tissue Doppler and strain variables. Results: A detailed analyses of key variables of cardiac dimensions and cardiac function revealed no significant differences between the two study groups. Conclusion: In this cohort of well-described ME/CFS patients, we found no significant differences in echocardiographic variables characterizing cardiac dimensions and function compared with healthy controls.

scholarly journals Spinal Fluid Abnormalities in Patients with Chronic Fatigue Syndrome

2005 ◽  
Vol 12 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Benjamin H. Natelson ◽  
Shelley A. Weaver ◽  
Chin-Lin Tseng ◽  
John E. Ottenweller
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Brain Dysfunction ◽  
Case Definition ◽  
Spinal Fluid ◽  
Healthy Controls ◽  
Normal Fluid ◽  
Protein Levels ◽  
Fatigue Syndrome ◽  
Psychogenic Illness

ABSTRACT Arguments exist as to the cause of chronic fatigue syndrome (CFS). Some think that it is an example of symptom amplification indicative of functional or psychogenic illness, while our group thinks that some CFS patients may have brain dysfunction. To further pursue our encephalopathy hypothesis, we did spinal taps on 31 women and 13 men fulfilling the 1994 case definition for CFS and on 8 women and 5 men serving as healthy controls. Our outcome measures were white blood cell count, protein concentration in spinal fluid, and cytokines detectable in spinal fluid. We found that significantly more CFS patients had elevations in either protein levels or number of cells than healthy controls (30 versus 0%), and 13 CFS patients had protein levels and cell numbers that were higher than laboratory norms; patients with abnormal fluid had a lower rate of having comorbid depression than those with normal fluid. In addition, of the 11 cytokines detectable in spinal fluid, (i) levels of granulocyte-macrophage colony-stimulating factor were lower in patients than controls, (ii) levels of interleukin-8 (IL-8) were higher in patients with sudden, influenza-like onset than in patients with gradual onset or in controls, and (iii) IL-10 levels were higher in the patients with abnormal spinal fluids than in those with normal fluid or controls. The results support two hypotheses: that some CFS patients have a neurological abnormality that may contribute to the clinical picture of the illness and that immune dysregulation within the central nervous system may be involved in this process.

scholarly journals The Disrupted and Realigned Self: Exploring the Narratives of New Zealanders with  Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2021 ◽  
Author(s):  
◽  
Lara Joyce Milka Bell
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Participant Observation ◽  
Physical Exertion ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Community Interactions ◽  
Self Identity ◽  
Authentic Self ◽  
Fatigue Syndrome ◽  
The Individual

<p>Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) causes pronounced, debilitating fatigue that is not alleviated by rest, along with muscle and joint weakness, pain, cognitive difficulties and can be worsened through mental and physical exertion. However, it is also without an aetiology, and there is little consensus amongst both medical and patient spheres as to what CFS/ME actually is. In this thesis I draw on interviews with people with CFS/ME and participant observation in a patient-led support group in order to explore the way in which CFS/ME shaped participants’ identities and narratives of the self. I argue that participants moved through two stages that I call ‘The Disrupted Self’ and ‘The Realigned Self’. Falling ill with CFS/ME rapidly disrupted participants’ understandings of the bodies, their position within their family and the community, interactions with doctors, and all the usual markers on which they had previously formed their self-identities. In this state, I argue that participants and those with whom they engaged viewed both CFS/ME and my participants as liminal, ‘betwixt and between’ (Turner 1969) social roles and contemporary New Zealand ideals of illness, the individual, and the ‘sick person’. As the initial disruption and confusion of falling ill subsided, however, my participants worked to develop a new secure self-identity, the ‘Realigned Self’. They move into a normalised long-term liminal state by prioritising their health, adjusting their expectations of their body, developing their own conception of the aetiology of CFS/ME and forming a positive narrative of their new lives. This identity work utilised wider cultural ideals about the active, responsibilised and authentic self; common to late modern contemporary life (Beck and Beck-Gernsheim 2001, Desjarlais 1994, Giddens 1991, Rose 1996). Yet this realignment was often not reflected in the views of my participants’ friends, families and doctors. This illustrates the diverse perspectives and different degrees of liminality that exist within experiences and narratives of CFS/ME and contested illnesses.</p>

Monitoring and Assessing Symptoms of Chronic Fatigue Syndrome: Use of Time Series Regression

1999 ◽  
Vol 85 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Leonard A. Jason ◽  
Warren W. Tryon ◽  
Renee R. Taylor ◽  
Caroline King ◽  
Erin L. Frankenberry ◽  
...  
Keyword(s):  
Time Series ◽  
Chronic Fatigue Syndrome ◽  
Physical Exertion ◽  
Chronic Fatigue ◽  
Time Series Regression ◽  
Use Of Time ◽  
Fatigue Syndrome ◽  
Prolonged Fatigue ◽  
Methodological Problems ◽  
Mental Exertion

Chronic Fatigue Syndrome's principal symptoms are severe and include prolonged fatigue and a number of other minor symptoms. Behavioral data collection methods were used in a case study to show some of the benefits that can be derived from monitoring symptoms hourly and daily. Using time series regression, several statistically significant correlates of fatigue were found both within days and between days. Perceived energy, physical exertion, and mental exertion were significantly related to fatigue in both analyses. Collection of such data may help resolve a number of theoretical and methodological problems in research on the Chronic Fatigue Syndrome.

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