Lymphocyte phenotype and function in the chronic fatigue syndrome

1993 ◽  
Vol 13 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Stephen E. Straus ◽  
Scott Fritz ◽  
Janet K. Dale ◽  
Barbara Gould ◽  
Warren Strober
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Lymphocyte Phenotype ◽  
And Function

scholarly journals Corrigendum: Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Jakob Theorell ◽  
Indre Bileviciute-Ljungar ◽  
Bianca Tesi ◽  
Heinrich Schlums ◽  
Mette Sophie Johnsgaard ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Cytotoxic Lymphocyte ◽  
Fatigue Syndrome ◽  
Lymphocyte Phenotype ◽  
And Function

scholarly journals Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

2017 ◽  
Vol 8 ◽  
Author(s):  
Jakob Theorell ◽  
Indre Bileviciute-Ljungar ◽  
Bianca Tesi ◽  
Heinrich Schlums ◽  
Mette Sophie Johnsgaard ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Cytotoxic Lymphocyte ◽  
Fatigue Syndrome ◽  
Lymphocyte Phenotype ◽  
And Function

scholarly journals Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome

2013 ◽  
Vol 11 (1) ◽  
pp. 68 ◽  
Author(s):  
Marta Curriu ◽  
Jorge Carrillo ◽  
Marta Massanella ◽  
Josepa Rigau ◽  
José Alegre ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Cell Phenotype ◽  
Fatigue Syndrome ◽  
And Function

scholarly journals Exercise and Sleep Deprivation Do Not Change Cytokine Expression Levels in Patients with Chronic Fatigue Syndrome

2013 ◽  
Vol 20 (11) ◽  
pp. 1736-1742 ◽  
Author(s):  
Toru Nakamura ◽  
Stephan Schwander ◽  
Robert Donnelly ◽  
Dane B. Cook ◽  
Felix Ortega ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sleep Deprivation ◽  
Proinflammatory Cytokines ◽  
Physical Exertion ◽  
Chronic Fatigue ◽  
Immune Dysregulation ◽  
Peripheral Blood Lymphocytes ◽  
Protein Levels ◽  
Fatigue Syndrome ◽  
And Function

ABSTRACTA major hypothesis regarding the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to be reflected in upregulated proinflammatory cytokines leading to the symptoms that are characteristic of this illness. Because the symptoms worsen with physical exertion or sleep loss, we hypothesized that we could use these stressors to magnify the underlying potential pathogenic abnormalities in the cytokine systems of people with CFS. We conducted repeat blood sampling for cytokine levels from healthy subjects and CFS patients during both postexercise and total sleep deprivation nights and assayed for protein levels in the blood samples, mRNA activity in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found that these environmental manipulations did not produce clinically significant upregulation of proinflammatory cytokines. These data do not support an important role of immune dysregulation in the genesis of stress-induced worsening of CFS.

scholarly journals Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia

2010 ◽  
Vol 17 (4) ◽  
pp. 582-587 ◽  
Author(s):  
Toru Nakamura ◽  
Stephan K. Schwander ◽  
Robert Donnelly ◽  
Felix Ortega ◽  
Fumiharu Togo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Interleukin 10 ◽  
Peripheral Blood Lymphocytes ◽  
Fatigue Syndrome ◽  
The Common ◽  
Cytokine Dysregulation ◽  
And Function ◽  
Anti Inflammatory Cytokine ◽  
Better Than

ABSTRACT The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.

scholarly journals Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 406
Author(s):  
Per Ole Iversen ◽  
Thomas Gero von Lueder ◽  
Kristin Reimers Kardel ◽  
Katarina Lien
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Lactate Production ◽  
Study Groups ◽  
Chronic Fatigue ◽  
Tissue Doppler ◽  
Myalgic Encephalomyelitis ◽  
Exercise Intolerance ◽  
Healthy Controls ◽  
Fatigue Syndrome ◽  
And Function

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition associated with several negative health outcomes. A hallmark of ME/CFS is decreased exercise capacity and often profound exercise intolerance. The causes of ME/CSF and its related symptoms are unknown, but there are indications of a dysregulated metabolism with impaired glycolytic vs oxidative energy balance. In line with this, we recently demonstrated abnormal lactate accumulation among ME/CFS patients compared with healthy controls after exercise testing. Here we examined if cardiac dimensions and function were altered in ME/CFS, as this could lead to increased lactate production. Methods: We studied 16 female ME/CFS patients and 10 healthy controls with supine transthoracic echocardiography, and we assessed cardiac dimensions and function by conventional echocardiographic and Doppler analysis as well as novel tissue Doppler and strain variables. Results: A detailed analyses of key variables of cardiac dimensions and cardiac function revealed no significant differences between the two study groups. Conclusion: In this cohort of well-described ME/CFS patients, we found no significant differences in echocardiographic variables characterizing cardiac dimensions and function compared with healthy controls.

scholarly journals Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203503 ◽  
Author(s):  
Taiwu Wang ◽  
Lei Yu ◽  
Cong Xu ◽  
Keli Pan ◽  
Minglu Mo ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Oral Microbiome ◽  
Microbiome Composition ◽  
Fatigue Syndrome ◽  
And Function

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

1999 ◽  
Vol 97 (3) ◽  
pp. 319 ◽  
Author(s):  
D.A. DUPREZ ◽  
M.L. DE BUYZERE ◽  
B. DRIEGHE ◽  
F. VANHAVERBEKE ◽  
Y. TAES ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Short Term ◽  
Fatigue Syndrome

Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome

2017 ◽  
Vol 33 (3) ◽  
pp. 158-165
Author(s):  
Natalia Calvo ◽  
Naia Sáez-Francàs ◽  
Sergi Valero ◽  
Jesús Castro-Marrero ◽  
José Alegre Martín ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Chronic Fatigue Syndrome ◽  
Personality Assessment ◽  
Chronic Fatigue ◽  
Specific Pattern ◽  
Harm Avoidance ◽  
Assessment Instrument ◽  
Compulsive Disorder ◽  
Fatigue Syndrome ◽  
Self Transcendence

Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects completed the Spanish versions of the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and the Temperament and Character Inventory-Revised (TCI-R). Results: 78 (48.1%) of the patients presented a Personality Disorder (PD), the most frequent being Cluster C, specifically Obsessive-compulsive disorder, followed by Avoidant disorder. PDs showed a specific pattern of correlation with temperament scales. All PD clusters correlated positively with Harm Avoidance and Self-Transcendence, and negatively with Reward Dependence, Self-Directedness, and Cooperativeness. In a logistic regression analysis, Self-Directedness and Cooperativeness predicted PD presence. The findings are consistent with previous studies in non-CFS samples and suggest that the combination of the Temperament and Character dimensions (low Self-Directedness and Cooperativeness and high Harm Avoidance and Self-Transcendence) correlates with PD severity, and that Self-Directedness and Cooperativeness are associated with PD presence in CFS patients. The integration of these two perspectives expands the current comprehension of personality pathology in CFS patients.

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