scholarly journals Rui Appelberg (1960-2020)

2020 ◽  
pp. IAI.00714-20
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Associate Editor ◽  
Innate Immune ◽  
Current Understanding ◽  
Host Innate Immune Response

Rui Appelberg passed away suddenly on August 8th 2020. His research tremendously contributed to our current understanding on the crosstalk between mycobacteria species and the host innate immune response. He was an exceptional member of the microbiology and immunology community, he acted as Associate Editor of The Journal of Immunology and belonged to the Editorial Board of Infection and Immunity. Rui will be terribly missed. Collaborators, mentees and friends wrote him the following tribute.

scholarly journals Genetic basis of host innate immune response in mastitis caused by Staphylococcus aureus

2012 ◽  
Vol 4 ◽  
pp. 405-409 ◽  
Author(s):  
Adrianna Pawlik ◽  
Grażyna Sender ◽  
Rafał Starzyński ◽  
Agnieszka Korwin-Kossakowska
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
Innate Immune Response ◽  
Genetic Basis ◽  
Innate Immune ◽  
Host Innate Immune Response

scholarly journals Toxoplasma  GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11

2020 ◽  
Vol 16 (5) ◽  
pp. e1008586 ◽  
Author(s):  
Debanjan Mukhopadhyay ◽  
David Arranz-Solís ◽  
Jeroen P. J. Saeij
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Host Innate Immune Response

scholarly journals Leptospira interrogans Catalase Is Required for Resistance to H2O2and for Virulence

2012 ◽  
Vol 80 (11) ◽  
pp. 3892-3899 ◽  
Author(s):  
Azad Eshghi ◽  
Kristel Lourdault ◽  
Gerald L. Murray ◽  
Thanatchaporn Bartpho ◽  
Rasana W. Sermswan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Immune Response ◽  
Innate Immune Response ◽  
Reactive Oxygen ◽  
Innate Immune ◽  
Leptospira Interrogans ◽  
Oxygen Species ◽  
Content Type ◽  
Host Innate Immune Response

ABSTRACTPathogenicLeptospiraspp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate immune response. In this study, we characterizedLeptospira interroganscatalase (KatE), the only annotated catalase found within pathogenicLeptospiraspecies, by assessing its role in resistance to H2O2-induced oxidative stress and during infection in hamsters. PathogenicL. interrogansbacteria had a 50-fold-higher survival rate under H2O2-induced oxidative stress than did saprophyticL. biflexabacteria, and this was predominantly catalase dependent. We also characterized KatE, the only annotated catalase found within pathogenicLeptospiraspecies. Catalase assays performed with recombinant KatE confirmed specific catalase activity, while protein fractionation experiments localized KatE to the bacterial periplasmic space. The insertional inactivation ofkatEin pathogenicLeptospirabacteria drastically diminished leptospiral viability in the presence of extracellular H2O2and reduced virulence in an acute-infection model. Combined, these results suggest thatL. interrogansKatE confersin vivoresistance to reactive oxygen species induced by the host innate immune response.

Sign in / Sign up

Export Citation Format

Share Document