scholarly journals Identity of Streptococcus mutans surface protein antigen III and wall-associated protein antigen A.

1995 ◽  
Vol 63 (2) ◽  
pp. 733-735 ◽  
Author(s):  
M W Russell ◽  
D J Harrington ◽  
R R Russell
Keyword(s):  
Streptococcus Mutans ◽  
Surface Protein ◽  
Protein Antigen ◽  
Antigen A

scholarly journals Saliva-binding region of Streptococcus mutans surface protein antigen.

1993 ◽  
Vol 61 (10) ◽  
pp. 4344-4349 ◽  
Author(s):  
M Nakai ◽  
N Okahashi ◽  
H Ohta ◽  
T Koga
Keyword(s):  
Streptococcus Mutans ◽  
Surface Protein ◽  
Protein Antigen ◽  
Binding Region

scholarly journals Characterization of a Cell-surface Protein Antigen of Hydrophilic Streptococcus mutans Strain GS-5

Microbiology ◽  
1989 ◽  
Vol 135 (4) ◽  
pp. 981-988 ◽  
Author(s):  
H. Ohta ◽  
H. Kato ◽  
N. Okahashi ◽  
I. Takahashi ◽  
S. Hamada ◽  
...  
Keyword(s):  
Cell Surface ◽  
Streptococcus Mutans ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein ◽  
A Cell

Contribution of cell surface protein antigen PAc of Streptococcus mutans to bacteremia

2006 ◽  
Vol 8 (1) ◽  
pp. 114-121 ◽  
Author(s):  
Kazuhiko Nakano ◽  
Masato Tsuji ◽  
Kaoru Nishimura ◽  
Ryota Nomura ◽  
Takashi Ooshima
Keyword(s):  
Cell Surface ◽  
Streptococcus Mutans ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein

A DNA Vaccine Encoding a Cell-surface Protein Antigen of Streptococcus mutans Protects Gnotobiotic Rats from Caries

2002 ◽  
Vol 81 (11) ◽  
pp. 784-787 ◽  
Author(s):  
M.W. Fan ◽  
Z. Bian ◽  
Z.X. Peng ◽  
Y. Zhong ◽  
Z. Chen ◽  
...  
Keyword(s):  
Dental Caries ◽  
Cell Surface ◽  
Streptococcus Mutans ◽  
Dna Vaccine ◽  
Recombinant Dna ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein ◽  
Igg Antibody ◽  
A Cell

A cell-surface protein antigen (PAc) of Streptococcus mutans is considered a virulence factor because it may mediate initial attachment of Streptococcus mutans to tooth surfaces. Thus, inhibiting PAc is predicted to provide protection against caries. To develop vaccines against dental caries, we constructed a DNA vaccine, pCIA-P, which encodes two high-conservative regions of PAc. Expression of the recombinant protein was obtained in eukaryotic cells in vitro and in vivo. In this report, we provide evidence that fewer caries lesions, and high levels of PAc-specific salivary IgA antibody and serum IgG antibody, were observed in gnotobiotic rats following targeted salivary gland (TSG) administration of pCIA-P. This study shows that the recombinant DNA vaccine pCIA-P could induce protective anti-caries immune responses and that TSG immunization is a promising strategy for the inhibition of dental caries.

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