scholarly journals Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection.

1996 ◽  
Vol 64 (12) ◽  
pp. 5332-5340 ◽  
Author(s):  
H L Mobley ◽  
R Belas ◽  
V Lockatell ◽  
G Chippendale ◽  
A L Trifillis ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Epithelial Cells ◽  
Tract Infection ◽  
Mouse Model ◽  
Proteus Mirabilis ◽  
Renal Epithelial Cells ◽  
Negative Mutant

scholarly journals Visualization of Proteus mirabilis within the Matrix of Urease-Induced Bladder Stones during Experimental Urinary Tract Infection

2002 ◽  
Vol 70 (1) ◽  
pp. 389-394 ◽  
Author(s):  
Xin Li ◽  
Hui Zhao ◽  
C. Virginia Lockatell ◽  
Cinthia B. Drachenberg ◽  
David E. Johnson ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Proteus Mirabilis ◽  
Laser Scanning ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Wild Type ◽  
Alizarin Red ◽  
Negative Mutant

ABSTRACT The virulence of a urease-negative mutant of uropathogenic Proteus mirabilis and its wild-type parent strain was assessed by using a CBA mouse model of catheterized urinary tract infection. Overall, catheterized mice were significantly more susceptible than uncatheterized mice to infection by wild-type P. mirabilis. At a high inoculum, the urease-negative mutant successfully colonized bladders of catheterized mice but did not cause urolithiasis and was still severely attenuated in its ability to ascend to kidneys. Using confocal laser scanning microscopy and scanning electron microscopy, we demonstrated the presence of P. mirabilis within the urease-induced stone matrix. Alizarin red S staining was used to detect calcium-containing deposits in bladder and kidney tissues of P. mirabilis-infected mice.

scholarly journals Construction of an MR/P fimbrial mutant of Proteus mirabilis: role in virulence in a mouse model of ascending urinary tract infection.

1994 ◽  
Vol 62 (8) ◽  
pp. 3363-3371 ◽  
Author(s):  
F K Bahrani ◽  
G Massad ◽  
C V Lockatell ◽  
D E Johnson ◽  
R G Russell ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Mouse Model ◽  
Proteus Mirabilis
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