scholarly journals CD95 Expression in Aged Mice Infected with Tuberculosis

1998 ◽  
Vol 66 (10) ◽  
pp. 5036-5040 ◽  
Author(s):  
A. D. Roberts ◽  
Ian M. Orme
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd4 T Cells ◽  
Activated T Cells ◽  
Homeostatic Mechanism ◽  
Aged Mice ◽  
Induction Of Apoptosis ◽  
Old Mice

ABSTRACT The interaction between CD95 and its ligand is an important homeostatic mechanism that leads to the induction of apoptosis in activated T cells. In view of recent evidence that this pathway might be defective in aged mice, this study investigated CD95 expression on T cells in old mice activated by infection with Mycobacterium tuberculosis. The results of the study do not support the hypothesis that CD95 is poorly expressed on CD4 T cells from old mice; instead, it was found that similar numbers of T cells from young and old mice expressed CD95, with the intensity of expression if anything higher on the cells from the old mice. In addition, the study demonstrated that changes in CD44 and CD45RB expression previously observed in young infected mice proceeded in a similar fashion in old animals and, as would be predicted, that CD95hi expression was primarily associated with CD4 T cells expressing the activated CD44hi CD45RBhi phenotype.

scholarly journals Cutting Edge: Control of Mycobacterium tuberculosis Infection by a Subset of Lung Parenchyma–Homing CD4 T Cells

2014 ◽  
Vol 192 (7) ◽  
pp. 2965-2969 ◽  
Author(s):  
Shunsuke Sakai ◽  
Keith D. Kauffman ◽  
Jason M. Schenkel ◽  
Cortez C. McBerry ◽  
Katrin D. Mayer-Barber ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd4 T Cells ◽  
Lung Parenchyma ◽  
Cutting Edge ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals A Subset of Circulating Blood Mycobacteria-Specific CD4 T Cells Can Predict the Time to Mycobacterium tuberculosis Sputum Culture Conversion

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102178 ◽  
Author(s):  
Catherine Riou ◽  
Clive M. Gray ◽  
Masixole Lugongolo ◽  
Thabisile Gwala ◽  
Agano Kiravu ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd4 T Cells ◽  
Sputum Culture ◽  
Sputum Culture Conversion ◽  
Culture Conversion

scholarly journals Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection

2010 ◽  
Vol 40 (8) ◽  
pp. 2211-2220 ◽  
Author(s):  
Nadia Caccamo ◽  
Giuliana Guggino ◽  
Simone A. Joosten ◽  
Giuseppe Gelsomino ◽  
Paola Di Carlo ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd4 T Cells ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB

Tuberculosis ◽  
2011 ◽  
Vol 91 (3) ◽  
pp. 224-230 ◽  
Author(s):  
L. El Fenniri ◽  
Z. Toossi ◽  
H. Aung ◽  
G. El Iraki ◽  
J. Bourkkadi ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Cd4 T Cells ◽  
Effector Memory ◽  
Specific Effector ◽  
Memory Cd4 T Cells

scholarly journals Synergistic Induction of Apoptosis in Primary CD4+T Cells by Macrophage-Tropic HIV-1 and TGF-β1

2001 ◽  
Vol 167 (6) ◽  
pp. 3360-3366 ◽  
Author(s):  
Jinhai Wang ◽  
Ennan Guan ◽  
Gregory Roderiquez ◽  
Michael A. Norcross
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Synergistic Induction ◽  
Induction Of Apoptosis ◽  
Hiv 1 ◽  
Tgf Β1

scholarly journals Expression Cloning of an Immunodominant Family of Mycobacterium tuberculosis Antigens Using Human Cd4+ T Cells

2000 ◽  
Vol 191 (3) ◽  
pp. 551-560 ◽  
Author(s):  
Mark R. Alderson ◽  
Teresa Bement ◽  
Craig H. Day ◽  
Liqing Zhu ◽  
David Molesh ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd4 T Cells ◽  
Mononuclear Cells ◽  
Genomic Library ◽  
Cell Epitope ◽  
Single Amino Acid ◽  
Expression Cloning ◽  
Peripheral Blood Mononuclear

Development of a subunit vaccine for Mycobacterium tuberculosis (Mtb) is likely to be dependent on the identification of T cell antigens that induce strong proliferation and interferon γ production from healthy purified protein derivative (PPD)+ donors. We have developed a sensitive and rapid technique for screening an Mtb genomic library expressed in Escherichia coli using Mtb-specific CD4+ T cells. Using this technique, we identified a family of highly related Mtb antigens. The gene of one family member encodes a 9.9-kD antigen, termed Mtb9.9A. Recombinant Mtb9.9A protein, expressed and purified from E. coli, elicited strong T cell proliferation and IFN-γ production by peripheral blood mononuclear cells from PPD+ but not PPD− individuals. Southern blot analysis and examination of the Mtb genome sequence revealed a family of highly related genes. A T cell line from a PPD+ donor that failed to react with recombinant Mtb9.9A recognized one of the other family members, Mtb9.9C. Synthetic peptides were used to map the T cell epitope recognized by this line, and revealed a single amino acid substitution in this region when compared with Mtb9.9A. The direct identification of antigens using T cells from immune donors will undoubtedly be critical for the development of vaccines to several intracellular pathogens.

scholarly journals Impairment in a negative regulatory system for TCR signaling in CD4+T cells from old mice

FEBS Letters ◽  
2007 ◽  
Vol 581 (16) ◽  
pp. 3039-3043 ◽  
Author(s):  
Mitsushi Inomata ◽  
Yukiko Shimada ◽  
Masami Hayashi ◽  
Jun Shimizu ◽  
Yoshiko Ohno-Iwashita
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Regulatory System ◽  
Tcr Signaling ◽  
Old Mice
Sign in / Sign up

Export Citation Format

Share Document