scholarly journals Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria

1998 ◽  
Vol 66 (9) ◽  
pp. 4093-4099 ◽  
Author(s):  
Véronique Amani ◽  
Mariama Idrissa Boubou ◽  
Sylviane Pied ◽  
Myriam Marussig ◽  
David Walliker ◽  
...  
Keyword(s):  
Survival Time ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Genetic Background ◽  
Clonal Diversity ◽  
Mouse Strains ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria ◽  
Mouse Genetic

ABSTRACT Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.

Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria

1998 ◽  
Vol 66 (9) ◽  
pp. 4093-4099 ◽  
Author(s):  
Véronique Amani ◽  
Mariama Idrissa Boubou ◽  
Sylviane Pied ◽  
Myriam Marussig ◽  
David Walliker ◽  
...  
Keyword(s):  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria

scholarly journals Susceptibility to Experimental Cerebral Malaria Induced by Plasmodium berghei ANKA in Inbred Mouse Strains Recently Derived from Wild Stock

2002 ◽  
Vol 70 (4) ◽  
pp. 2049-2056 ◽  
Author(s):  
S. Bagot ◽  
M. Idrissa Boubou ◽  
S. Campino ◽  
C. Behrschmidt ◽  
O. Gorgette ◽  
...  
Keyword(s):  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Inbred Mouse ◽  
Laboratory Mouse ◽  
Mouse Strains ◽  
Gene Pools ◽  
Experimental Cerebral Malaria ◽  
Mhc Molecules ◽  
Mhc Haplotype ◽  
Common Laboratory

ABSTRACT The neurological syndrome caused by Plasmodium berghei ANKA in rodents partially mimics the human disease. Several rodent models of cerebral malaria (CM) exist for the study of the mechanisms that cause the disease. However, since common laboratory mouse strains have limited gene pools, the role of their phenotypic variations causing CM is restricted. This constitutes an obstacle for efficient genetic analysis relating to the pathogenesis of malaria. Most common laboratory mouse strains are susceptible to CM, and the same major histocompatibility complex (MHC) haplotype may exhibit different levels of susceptibility. We analyzed the influence of the MHC haplotype on overcoming CM by using MHC congenic mice with C57BL/10 and C3H backgrounds. No correlation was found between MHC molecules and the development of CM. New wild-derived mouse strains with wide genetic polymorphisms were then used to find new models of resistance to CM. Six of the twelve strains tested were resistant to CM. For two of them, F1 progeny and backcrosses performed with the reference strain C57BL/6 showed a high level of heterogeneity in the number and characteristics of the genetic factors associated with resistance to CM.

scholarly journals Efficacy of Different Nitric Oxide-Based Strategies in Preventing Experimental Cerebral Malaria by Plasmodium berghei ANKA

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32048 ◽  
Author(s):  
Yuri C. Martins ◽  
Graziela M. Zanini ◽  
John A. Frangos ◽  
Leonardo J. M. Carvalho
Keyword(s):  
Nitric Oxide ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria

Ginger Extract Has An Ability To Safe C57BL / 6-WT Mice From Cerebral Malaria Produced By Plasmodium Berghei ANKA

2018 ◽  
pp. 1
Author(s):  
سالم رمضان على السريتى ◽  
نوارة امراجع الازيرق العمارى
Keyword(s):  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Ginger Extract

scholarly journals Efficacy of Proveblue (Methylene Blue) in an Experimental Cerebral Malaria Murine Model

2013 ◽  
Vol 57 (7) ◽  
pp. 3412-3414 ◽  
Author(s):  
Jérome Dormoi ◽  
Sébastien Briolant ◽  
Camille Desgrouas ◽  
Bruno Pradines
Keyword(s):  
Methylene Blue ◽  
Cerebral Malaria ◽  
Murine Model ◽  
Plasmodium Berghei ◽  
Active Metabolite ◽  
Line Treatment ◽  
First Line ◽  
Experimental Cerebral Malaria ◽  
Content Type ◽  
First Line Treatment

ABSTRACTAlthough 100% of untreated mice infected withPlasmodium bergheidied with specific signs of cerebral malaria and 100% of mice treated with 3 mg/kg dihydroartemisinin, the active metabolite of artesunate, which is used as the first-line treatment for severe malaria, also died but showed no specific signs of cerebral malaria, 78% of mice treated with 10 mg/kg Proveblue (methylene blue) and 78% of mice treated with a combination of 3 mg dihydroartemisinin and 10 mg/kg Proveblue survived and showed no specific signs of cerebral malaria or detectable parasites.

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