scholarly journals Efficacy of Different Nitric Oxide-Based Strategies in Preventing Experimental Cerebral Malaria by Plasmodium berghei ANKA

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32048 ◽  
Author(s):  
Yuri C. Martins ◽  
Graziela M. Zanini ◽  
John A. Frangos ◽  
Leonardo J. M. Carvalho
Keyword(s):  
Nitric Oxide ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria

Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria

1998 ◽  
Vol 66 (9) ◽  
pp. 4093-4099 ◽  
Author(s):  
Véronique Amani ◽  
Mariama Idrissa Boubou ◽  
Sylviane Pied ◽  
Myriam Marussig ◽  
David Walliker ◽  
...  
Keyword(s):  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria

scholarly journals Cutting Edge: Selective Blockade of LIGHT-Lymphotoxin β Receptor Signaling Protects Mice from Experimental Cerebral Malaria Caused by Plasmodium berghei ANKA

2008 ◽  
Vol 181 (11) ◽  
pp. 7458-7462 ◽  
Author(s):  
Louise M. Randall ◽  
Fiona H. Amante ◽  
Yonghong Zhou ◽  
Amanda C. Stanley ◽  
Ashraful Haque ◽  
...  
Keyword(s):  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Cutting Edge ◽  
Receptor Signaling ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria ◽  
Selective Blockade ◽  
Β Receptor

Plasmodium berghei ANKA: Erythropoietin activates neural stem cells in an experimental cerebral malaria model

2011 ◽  
Vol 127 (2) ◽  
pp. 500-505 ◽  
Author(s):  
Andrew Core ◽  
Casper Hempel ◽  
Jørgen A.L. Kurtzhals ◽  
Milena Penkowa
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria ◽  
Malaria Model

scholarly journals Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria

1998 ◽  
Vol 66 (9) ◽  
pp. 4093-4099 ◽  
Author(s):  
Véronique Amani ◽  
Mariama Idrissa Boubou ◽  
Sylviane Pied ◽  
Myriam Marussig ◽  
David Walliker ◽  
...  
Keyword(s):  
Survival Time ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Genetic Background ◽  
Clonal Diversity ◽  
Mouse Strains ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria ◽  
Mouse Genetic

ABSTRACT Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.

Blood–cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA

2020 ◽  
Vol 50 (14) ◽  
pp. 1167-1175
Author(s):  
Ha Ngo-Thanh ◽  
Tsutomu Sasaki ◽  
Kazutomo Suzue ◽  
Hideaki Yokoo ◽  
Koji Isoda ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Experimental Cerebral Malaria

Ginger Extract Has An Ability To Safe C57BL / 6-WT Mice From Cerebral Malaria Produced By Plasmodium Berghei ANKA

2018 ◽  
pp. 1
Author(s):  
سالم رمضان على السريتى ◽  
نوارة امراجع الازيرق العمارى
Keyword(s):  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Plasmodium Berghei Anka ◽  
Ginger Extract

scholarly journals Efficacy of Proveblue (Methylene Blue) in an Experimental Cerebral Malaria Murine Model

2013 ◽  
Vol 57 (7) ◽  
pp. 3412-3414 ◽  
Author(s):  
Jérome Dormoi ◽  
Sébastien Briolant ◽  
Camille Desgrouas ◽  
Bruno Pradines
Keyword(s):  
Methylene Blue ◽  
Cerebral Malaria ◽  
Murine Model ◽  
Plasmodium Berghei ◽  
Active Metabolite ◽  
Line Treatment ◽  
First Line ◽  
Experimental Cerebral Malaria ◽  
Content Type ◽  
First Line Treatment

ABSTRACTAlthough 100% of untreated mice infected withPlasmodium bergheidied with specific signs of cerebral malaria and 100% of mice treated with 3 mg/kg dihydroartemisinin, the active metabolite of artesunate, which is used as the first-line treatment for severe malaria, also died but showed no specific signs of cerebral malaria, 78% of mice treated with 10 mg/kg Proveblue (methylene blue) and 78% of mice treated with a combination of 3 mg dihydroartemisinin and 10 mg/kg Proveblue survived and showed no specific signs of cerebral malaria or detectable parasites.

Establishment of a murine model of cerebral malaria in KunMing mice infected with Plasmodium berghei ANKA

Parasitology ◽  
2016 ◽  
Vol 143 (12) ◽  
pp. 1672-1680 ◽  
Author(s):  
YAN DING ◽  
WENYUE XU ◽  
TAOLI ZHOU ◽  
TAIPING LIU ◽  
HONG ZHENG ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Cerebral Malaria ◽  
Plasmodium Berghei ◽  
Blood Cells ◽  
Mononuclear Cells ◽  
Clinical Signs ◽  
Necrosis Factor Alpha ◽  
Experimental Cerebral Malaria ◽  
Km Mice

SUMMARYMalaria remains one of the most devastating diseases. Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection resulting in high mortality and morbidity worldwide. Analysis of precise mechanisms of CM in humans is difficult for ethical reasons and animal models of CM have been employed to study malaria pathogenesis. Here, we describe a new experimental cerebral malaria (ECM) model with Plasmodium berghei ANKA infection in KunMing (KM) mice. KM mice developed ECM after blood-stage or sporozoites infection, and the development of ECM in KM mice has a dose-dependent relationship with sporozoites inoculums. Histopathological findings revealed important features associated with ECM, including accumulation of mononuclear cells and red blood cells in brain microvascular, and brain parenchymal haemorrhages. Blood–brain barrier (BBB) examination showed that BBB disruption was present in infected KM mice when displaying clinical signs of CM. In vivo bioluminescent imaging experiment indicated that parasitized red blood cells accumulated in most vital organs including heart, lung, spleen, kidney, liver and brain. The levels of inflammatory cytokines interferon-gamma, tumour necrosis factor-alpha, interleukin (IL)-17, IL-12, IL-6 and IL-10 were all remarkably increased in KM mice infected with P. berghei ANKA. This study indicates that P. berghei ANKA infection in KM mice can be used as ECM model to extend further research on genetic, pharmacological and vaccine studies of CM.

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